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Literature summary extracted from

  • Angliker, H.; Neumann, U.; Molloy, S.S.; Thomas, G.
    Internally quenched fluorogenic substrate for furin (1995), Anal. Biochem., 224, 409-412.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.75 0.002
-
 protective antigen (-Arg-Lys-Lys-Arg-Ser-Thr-Ser-Ala-Gly-) Mammalia
3.4.21.75 0.0038
-
 2-Aminobenzoyl-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH
-
 Mammalia
3.4.21.75 0.0156
-
 tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide
-
 Mammalia

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.75 Mammalia
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.75 2-Aminobenzoyl-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH + H2O
-
 Mammalia ?
-
 ?
3.4.21.75 protective antigen + H2O
-
 Mammalia ?
-
 ?
3.4.21.75 tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Mammalia tert-butoxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.75 37
-
 assay at Mammalia

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.75 0.192
-
 tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide
-
 Mammalia
3.4.21.75 11
-
 protective antigen (-Arg-Lys-Lys-Arg-Ser-Thr-Ser-Ala-Gly-) Mammalia
3.4.21.75 29.3
-
 2-Aminobenzoyl-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH
-
 Mammalia