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Literature summary extracted from

  • Hatsuzawa, K.; Murakami, K.; Nakayama, K.
    Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites (1992), J. Biochem., 111, 296-301.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.75
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.75 antipain moderately Mus musculus
3.4.21.75 Cu2+
-
 Mus musculus
3.4.21.75 diisopropyl fluorophosphate
-
 Mus musculus
3.4.21.75 EDTA
-
 Mus musculus
3.4.21.75 Hg2+
-
 Mus musculus
3.4.21.75 leupeptin moderately Mus musculus
3.4.21.75 NEM moderately Mus musculus
3.4.21.75 p-chloromercuribenzenesulfonic acid
-
 Mus musculus
3.4.21.75 Zn2+
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.75 Golgi trans-face human, mainly, the enzyme can translocate between the cell surface and the trans-Golgi network Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.75 Ca2+ required Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.75 Mus musculus
-
 expression in Chinese hamster ovary cells
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.75 Prorenin + H2O
-
 Mus musculus ?
-
 ?
3.4.21.75 Protein precursor + H2O
-
 Mus musculus ?
-
 ?
3.4.21.75 tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Mus musculus tert-butoxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.75 6.5 7.5 tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide Mus musculus
3.4.21.75 7
-
 around, tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide Mus musculus