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Literature summary extracted from

  • Wang, C.I.; Yang, Q.; Craik, C.S.
    Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin (1995), J. Biol. Chem., 270, 12250-12256.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 ecotin inhibits uPA almost 10000-fold less efficiently than trypsin, ecotin is expressed on the surface of filamentous bacteriophage, each of the selected ecotin variants (M84R, M84K, M84R/M85R and M84R/M85K) exhibits increased affinity for uPA when compared to wild-type ecotin, with ecotin M84R/M85R showing 2800-fold increase in binding affinity Homo sapiens
3.4.21.73 Trypsin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
 commercial preparation of low-molecular weight uPA from American Diagnostica
-
3.4.21.73 Mammalia
-
 commercial preparation of low-molecular weight uPA from American Diagnostica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?