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Literature summary extracted from

  • Wang, N.; Gottesman, S.; Willingham, M.C.; Gottesman, M.M.; Maurizi, M.R.
    A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease (1993), Proc. Natl. Acad. Sci. USA, 90, 11247-11251.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.53 cDNA clone pHHCPK77, 51 kDa fragment expressed in Escherichia coli BL21(DE3) Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.53 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.53 additional information
-
 amino acid sequence compared to other Lon-protein sequences Escherichia coli
3.4.21.53 additional information
-
 amino acid sequence compared to other Lon-protein sequences Homo sapiens
3.4.21.53 additional information
-
 amino acid sequence compared to other Lon-protein sequences Brevibacillus brevis
3.4.21.53 additional information
-
 amino acid sequence compared to other Lon-protein sequences Myxococcus xanthus
3.4.21.53 100000
-
 Western blotting Homo sapiens
3.4.21.53 106000
-
 calculated from cDNA Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.53 Brevibacillus brevis
-
-
-
3.4.21.53 Escherichia coli
-
-
-
3.4.21.53 Homo sapiens
-
-
-
3.4.21.53 Homo sapiens P36776 human
-
3.4.21.53 Myxococcus xanthus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.53 recombinant enzyme Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.53 brain hippocampus, human Homo sapiens
-
3.4.21.53 additional information expression in human tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.53 casein + H2O alpha-casein Brevibacillus brevis hydrolyzed casein
-
 ?
3.4.21.53 casein + H2O alpha-casein Escherichia coli hydrolyzed casein
-
 ?
3.4.21.53 casein + H2O alpha-casein Homo sapiens hydrolyzed casein
-
 ?
3.4.21.53 casein + H2O alpha-casein Myxococcus xanthus hydrolyzed casein
-
 ?
3.4.21.53 Succinyl-Phe-Ala-Phe-methoxynaphthylamide + H2O
-
 Escherichia coli Succinyl-Phe-Ala-Phe + methoxynaphthylamine
-
 ?
3.4.21.53 Succinyl-Phe-Ala-Phe-methoxynaphthylamide + H2O
-
 Homo sapiens Succinyl-Phe-Ala-Phe + methoxynaphthylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.53 human ATP-dependent protease
-
 Homo sapiens
3.4.21.53 human lon protease
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.53 37
-
 assay at Brevibacillus brevis
3.4.21.53 37
-
 assay at Escherichia coli
3.4.21.53 37
-
 assay at Homo sapiens
3.4.21.53 37
-
 assay at Myxococcus xanthus

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.53 ATP ATP-dependent protease Escherichia coli
3.4.21.53 ATP ATP-dependent protease Homo sapiens
3.4.21.53 ATP ATP-dependent protease Brevibacillus brevis
3.4.21.53 ATP ATP-dependent protease Myxococcus xanthus
3.4.21.53 ATP
-
 Homo sapiens