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Literature summary extracted from

  • Okuno, E.; Kido, R.
    Kynureninase and kynurenine 3-hydroxylase in mammalian tissues (1991), Adv. Exp. Med. Biol., 294, 167-176.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.7.1.3 medicine tryptophan metabolism Homo sapiens
3.7.1.3 medicine tryptophan metabolism Rattus norvegicus
3.7.1.3 medicine tryptophan metabolism Suncus murinus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.7.1.3 0.013
-
 L-3-hydroxykynurenine
-
 Rattus norvegicus
3.7.1.3 0.018
-
 L-3-hydroxykynurenine
-
 Suncus murinus
3.7.1.3 0.077
-
 L-3-hydroxykynurenine
-
 Homo sapiens
3.7.1.3 0.24
-
 L-kynurenine
-
 Rattus norvegicus
3.7.1.3 0.25
-
 L-kynurenine
-
 Suncus murinus
3.7.1.3 1
-
 L-kynurenine
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.7.1.3 95000
-
-
 Rattus norvegicus
3.7.1.3 110000
-
-
 Suncus murinus
3.7.1.3 130000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.7.1.3 3-hydroxy-L-kynurenine + H2O Homo sapiens
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O Rattus norvegicus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O Suncus murinus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 L-kynurenine + H2O Homo sapiens
-
 anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O Rattus norvegicus
-
 anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O Suncus murinus
-
 anthranilate + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.3 Homo sapiens
-
-
-
3.7.1.3 Rattus norvegicus
-
-
-
3.7.1.3 Suncus murinus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.7.1.3 adrenal gland
-
 Homo sapiens
-
3.7.1.3 adrenal gland
-
 Rattus norvegicus
-
3.7.1.3 adrenal gland
-
 Suncus murinus
-
3.7.1.3 brain
-
 Homo sapiens
-
3.7.1.3 brain
-
 Rattus norvegicus
-
3.7.1.3 brain
-
 Suncus murinus
-
3.7.1.3 heart
-
 Homo sapiens
-
3.7.1.3 heart
-
 Rattus norvegicus
-
3.7.1.3 heart
-
 Suncus murinus
-
3.7.1.3 intestinal muscle
-
 Homo sapiens
-
3.7.1.3 intestinal muscle
-
 Rattus norvegicus
-
3.7.1.3 intestinal muscle
-
 Suncus murinus
-
3.7.1.3 kidney
-
 Homo sapiens
-
3.7.1.3 kidney
-
 Rattus norvegicus
-
3.7.1.3 kidney
-
 Suncus murinus
-
3.7.1.3 liver
-
 Homo sapiens
-
3.7.1.3 liver
-
 Rattus norvegicus
-
3.7.1.3 liver
-
 Suncus murinus
-
3.7.1.3 lung
-
 Homo sapiens
-
3.7.1.3 lung
-
 Rattus norvegicus
-
3.7.1.3 lung
-
 Suncus murinus
-
3.7.1.3 muscle
-
 Rattus norvegicus
-
3.7.1.3 muscle
-
 Suncus murinus
-
3.7.1.3 ovary
-
 Homo sapiens
-
3.7.1.3 pancreas
-
 Homo sapiens
-
3.7.1.3 pancreas
-
 Rattus norvegicus
-
3.7.1.3 pancreas
-
 Suncus murinus
-
3.7.1.3 spleen
-
 Homo sapiens
-
3.7.1.3 spleen
-
 Rattus norvegicus
-
3.7.1.3 spleen
-
 Suncus murinus
-
3.7.1.3 thymus
-
 Suncus murinus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.7.1.3 0.0002
-
 liver Rattus norvegicus
3.7.1.3 0.0007
-
 liver Homo sapiens
3.7.1.3 0.026
-
 liver Suncus murinus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Homo sapiens 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Suncus murinus 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Homo sapiens 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Suncus murinus 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Homo sapiens anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Rattus norvegicus anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Suncus murinus anthranilate + L-alanine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.7.1.3 dimer
-
 Rattus norvegicus
3.7.1.3 dimer
-
 Suncus murinus