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Literature summary extracted from

  • Tanizawa, K.; Soda, K.
    Inducible and constitutive kynureninases. Control of the inducible enzyme activity by transamination and inhibition of the constitutive enzyme by 3-hydroxyanthranilate (1979), J. Biochem., 86, 499-508.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.7.1.3 pyridoxal 5'-phosphate
-
 Sus scrofa
3.7.1.3 pyridoxal 5'-phosphate in the presence of pyruvate Neurospora crassa
3.7.1.3 pyridoxamine phosphate in the presence of pyruvate Neurospora crassa

Application

EC Number Application Comment Organism
3.7.1.3 medicine tryptophan metabolism Sus scrofa
3.7.1.3 medicine tryptophan metabolism Neurospora crassa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.7.1.3 3-Hydroxyanthranilate 0.001 mM in 0.06 mM Tris-HCl buffer Sus scrofa
3.7.1.3 anthranilic acid
-
 Neurospora crassa
3.7.1.3 delta-N-acetyl-L-ornithine 0.001 mM in 0.06 mM Tris-HCl buffer Neurospora crassa
3.7.1.3 Kynurenate
-
 Neurospora crassa
3.7.1.3 Kynurenate 0.001 mM in 0.06 mM Tris-HCl buffer Sus scrofa
3.7.1.3 L-alanine
-
 Neurospora crassa
3.7.1.3 L-lysine
-
 Neurospora crassa
3.7.1.3 L-ornithine
-
 Neurospora crassa
3.7.1.3 quinaldinate
-
 Neurospora crassa
3.7.1.3 quinaldinate 0.001 mM in 0.06 mM Tris-HCl buffer Sus scrofa
3.7.1.3 S-(beta-aminoethyl)-L-cysteine 0.001 mM in 0.06 mM Tris-HCl buffer Neurospora crassa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.7.1.3 11
-
 L-alanine
-
 Neurospora crassa
3.7.1.3 40
-
 L-ornithine
-
 Neurospora crassa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.7.1.3 105000
-
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.7.1.3 L-kynurenine + H2O Sus scrofa
-
 anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O Neurospora crassa
-
 anthranilate + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.3 Neurospora crassa
-
-
-
3.7.1.3 Sus scrofa
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.7.1.3 12.56
-
-
 Neurospora crassa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.3 L-kynurenine + H2O
-
 Sus scrofa anthranilate + L-alanine
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Neurospora crassa anthranilate + L-alanine
-
 ?
3.7.1.3 L-ornithine + H2O
-
 Neurospora crassa ?
-
 ?