Literature summary extracted from

Nagainis, M.P.; Pu, W.; Cheng, B.; Taylor, K.E.; Schmidt, Jr., D.E.
Effects of pH and sulfhydryl specific reagents on 4-fumarylacetoacetate fumarylhydrolase (1981), Biochim. Biophys. Acta, 657, 203-211.

Application

EC Number	Application	Comment	Organism
3.7.1.2	medicine	plays a role in hereditary tyrosinemia	Bos taurus
3.7.1.2	medicine	plays a role in degradation pathway of phenylalanine and tyrosine	Bos taurus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.7.1.2	5,5'-dithiobis(2-nitrobenzoic acid)	-	Bos taurus
3.7.1.2	p-hydroxymercuribenzoate	-	Bos taurus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.7.1.2	2.3	6	propionopyruvate	dependent on pH	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.7.1.2	intracellular	-	Bos taurus	5622	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.7.1.2	87000	-	gel filtration	Bos taurus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.7.1.2	4-fumarylacetoacetate + H2O	Bos taurus	-	acetoacetate + fumarate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.7.1.2	Bos taurus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.7.1.2	-	Bos taurus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.7.1.2	liver	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.7.1.2	4-fumarylacetoacetate + H2O	-	Bos taurus	acetoacetate + fumarate	-	?
3.7.1.2	propionopyruvate + H2O	-	Bos taurus	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.7.1.2	dimer	2 * 40000-43000, gel filtration	Bos taurus

pH Range

EC Number	pH Minimum	pH Maximum	Comment	Organism
3.7.1.2	6.25	8.5	-	Bos taurus

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Release 2023.1 (January 2023)