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Literature summary extracted from

  • Maley, F.; Maley, G.F.
    A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase (1990), Prog. Nucleic Acid Res. Mol. Biol., 39, 49-80.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.12 dCTP
-
Bacillus subtilis
3.5.4.12 dCTP
-
Saccharomyces cerevisiae
3.5.4.12 dCTP
-
Herpes simplex virus
3.5.4.12 dCTP positive allosteric effector Gallus gallus
3.5.4.12 dCTP positive allosteric effector Homo sapiens
3.5.4.12 dCTP positive allosteric effector Rattus norvegicus
3.5.4.12 dCTP positive allosteric effector Tequatrovirus T4
3.5.4.12 dCTP positive allosteric effector Equus asinus
3.5.4.12 dCTP positive allosteric effector Escherichia phage T2
3.5.4.12 dCTP positive allosteric effector Enterobacteria phage T6
3.5.4.12 dCTP activation by dCTP is reversed by addition of dTTP Gallus gallus
3.5.4.12 dCTP activation by dCTP is reversed by addition of dTTP Homo sapiens
3.5.4.12 dCTP dCTP promotes an aggregation of enzyme subunits to the active state Gallus gallus
3.5.4.12 dCTP dCTP promotes an aggregation of enzyme subunits to the active state Escherichia phage T2

Application

EC Number Application Comment Organism
3.5.4.12 medicine associated mainly with dividing tissues, potential diagnostic tool for various disease states in which enzyme is elevated Homo sapiens
3.5.4.12 pharmacology might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents Equus asinus
3.5.4.12 pharmacology enzyme might be a reasonable target for chemotherapeutic agents directed against parasitic as well as neoplastic diseases by limiting the synthesis of dUMP, particularly when used in combination with inhibitors of dTMP synthase or other purine and pyrimidine inhibitors of DNA synthesis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.12
-
Tequatrovirus T4

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.4.12
-
Escherichia phage T2

General Stability

EC Number General Stability Organism
3.5.4.12 dCTP stabilizes Gallus gallus
3.5.4.12 dCTP stabilizes Tequatrovirus T4
3.5.4.12 dCTP stabilizes Escherichia phage T2
3.5.4.12 dCTP stabilizing hexameric state, dTTP destabilizing Equus asinus
3.5.4.12 dCTP stabilizing hexameric state, dTTP destabilizing Escherichia phage T2
3.5.4.12 enzyme is unstable Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.12 dTTP allosteric inhibitor Enterobacteria phage T6
3.5.4.12 dTTP allosteric inhibitor Equus asinus
3.5.4.12 dTTP allosteric inhibitor; dTTP favores disaggregated or inhibited state Escherichia phage T2
3.5.4.12 dTTP allosteric inhibitor; dTTP favores disaggregated or inhibited state Gallus gallus
3.5.4.12 dTTP
-
Herpes simplex virus
3.5.4.12 dTTP allosteric inhibitor Homo sapiens
3.5.4.12 dTTP allosteric inhibitor Rattus norvegicus
3.5.4.12 dTTP allosteric inhibitor Tequatrovirus T4

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.12 additional information
-
additional information
-
Gallus gallus
3.5.4.12 additional information
-
additional information
-
Bacillus subtilis
3.5.4.12 additional information
-
additional information
-
Homo sapiens
3.5.4.12 additional information
-
additional information
-
Rattus norvegicus
3.5.4.12 additional information
-
additional information
-
Saccharomyces cerevisiae
3.5.4.12 additional information
-
additional information
-
Tequatrovirus T4
3.5.4.12 additional information
-
additional information
-
Equus asinus
3.5.4.12 additional information
-
additional information
-
Escherichia phage T2

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.12 20000
-
6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Gallus gallus providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Bacillus subtilis providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Homo sapiens providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Rattus norvegicus providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Saccharomyces cerevisiae providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Tequatrovirus T4 providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Echinoidea providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Equus asinus providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Herpes simplex virus providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Escherichia phage T2 providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Betapolyomavirus macacae providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Enterobacteria phage T6 providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Polyomavirus sp. providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Gallus gallus importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Bacillus subtilis importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Homo sapiens importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Rattus norvegicus importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Saccharomyces cerevisiae importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Tequatrovirus T4 importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Echinoidea importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Equus asinus importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Herpes simplex virus importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Escherichia phage T2 importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Betapolyomavirus macacae importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Enterobacteria phage T6 importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Polyomavirus sp. importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides dUMP + NH3
-
?
3.5.4.12 additional information Homo sapiens
-
?
-
?
3.5.4.12 additional information Tequatrovirus T4 function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.12 Bacillus subtilis
-
-
-
3.5.4.12 Betapolyomavirus macacae
-
induced by
-
3.5.4.12 Echinoidea
-
-
-
3.5.4.12 Enterobacteria phage T6
-
T2-, T4-, and T6-phage induced enzyme in Escherichia coli
-
3.5.4.12 Equus asinus
-
donkey
-
3.5.4.12 Escherichia phage T2
-
T2-, T4-, and T6-phage induced enzyme in Escherichia coli
-
3.5.4.12 Escherichia phage T2
-
T2-phage infected Escherichia coli
-
3.5.4.12 Escherichia phage T2
-
T2r+-infected Escherichia coli B
-
3.5.4.12 Gallus gallus
-
-
-
3.5.4.12 Herpes simplex virus
-
induced by
-
3.5.4.12 Homo sapiens
-
human
-
3.5.4.12 no activity in Escherichia coli
-
enzyme not detectable in Escherichia coli until after infection with T-even bacteriophage
-
3.5.4.12 no activity in Escherichia coli
-
wild type Escherichia coli contains no dCMP deaminase
-
3.5.4.12 no activity in Salmonella typhimurium
-
do not contain dCMP deaminase
-
3.5.4.12 Polyomavirus sp.
-
induced by
-
3.5.4.12 Rattus norvegicus
-
-
-
3.5.4.12 Saccharomyces cerevisiae
-
-
-
3.5.4.12 Tequatrovirus T4
-
T2-, T4-, and T6-phage induced enzyme in Escherichia coli
-
3.5.4.12 Tequatrovirus T4
-
T4-phage infected Escherichia coli
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.12
-
Gallus gallus
3.5.4.12 HeLa cells Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Gallus gallus
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Bacillus subtilis
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Homo sapiens
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Rattus norvegicus
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Tequatrovirus T4
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Equus asinus
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Escherichia phage T2
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Enterobacteria phage T6
3.5.4.12 dCMP + H2O = dUMP + NH3 feedback regulation Gallus gallus
3.5.4.12 dCMP + H2O = dUMP + NH3 feedback regulation Homo sapiens
3.5.4.12 dCMP + H2O = dUMP + NH3 feedback regulation Rattus norvegicus
3.5.4.12 dCMP + H2O = dUMP + NH3 feedback regulation Tequatrovirus T4
3.5.4.12 dCMP + H2O = dUMP + NH3 feedback regulation Equus asinus
3.5.4.12 dCMP + H2O = dUMP + NH3 feedback regulation Escherichia phage T2
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Gallus gallus
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Bacillus subtilis
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Homo sapiens
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Rattus norvegicus
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Tequatrovirus T4
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Equus asinus
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Escherichia phage T2
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Enterobacteria phage T6

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.12 egg
-
Echinoidea
-
3.5.4.12 embryo
-
Gallus gallus
-
3.5.4.12 embryo
-
Rattus norvegicus
-
3.5.4.12 HeLa cell
-
Homo sapiens
-
3.5.4.12 liver
-
Rattus norvegicus
-
3.5.4.12 additional information associated mainly with dividing tissues Gallus gallus
-
3.5.4.12 additional information associated mainly with dividing tissues Bacillus subtilis
-
3.5.4.12 additional information associated mainly with dividing tissues Homo sapiens
-
3.5.4.12 additional information associated mainly with dividing tissues Rattus norvegicus
-
3.5.4.12 additional information associated mainly with dividing tissues Saccharomyces cerevisiae
-
3.5.4.12 additional information associated mainly with dividing tissues Tequatrovirus T4
-
3.5.4.12 additional information associated mainly with dividing tissues Echinoidea
-
3.5.4.12 additional information associated mainly with dividing tissues Equus asinus
-
3.5.4.12 additional information associated mainly with dividing tissues Herpes simplex virus
-
3.5.4.12 additional information associated mainly with dividing tissues Escherichia phage T2
-
3.5.4.12 additional information associated mainly with dividing tissues Betapolyomavirus macacae
-
3.5.4.12 additional information associated mainly with dividing tissues Enterobacteria phage T6
-
3.5.4.12 additional information associated mainly with dividing tissues Polyomavirus sp.
-
3.5.4.12 spleen
-
Homo sapiens
-
3.5.4.12 spleen
-
Equus asinus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.12 500
-
HeLa cells Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.12 5-bromo-dCMP + H2O
-
Saccharomyces cerevisiae 5-bromo-dUMP + NH3
-
?
3.5.4.12 5-bromo-dCMP + H2O
-
Equus asinus 5-bromo-dUMP + NH3
-
?
3.5.4.12 5-bromo-dCMP + H2O
-
Escherichia phage T2 5-bromo-dUMP + NH3
-
?
3.5.4.12 5-bromo-dCMP + H2O very good substrate Gallus gallus 5-bromo-dUMP + NH3
-
?
3.5.4.12 5-fluoro-dCMP + H2O
-
Saccharomyces cerevisiae 5-fluoro-dUMP + NH3
-
?
3.5.4.12 5-fluoro-dCMP + H2O
-
Equus asinus 5-fluoro-dUMP + NH3
-
?
3.5.4.12 5-fluoro-dCMP + H2O very good substrate Gallus gallus 5-fluoro-dUMP + NH3
-
?
3.5.4.12 5-fluoro-dCMP + H2O very good substrate Escherichia phage T2 5-fluoro-dUMP + NH3
-
?
3.5.4.12 5-Hg-dCMP + H2O deamination activated by dTTP and inhibited by dCTP Homo sapiens 5-Hg-dUMP + NH3
-
?
3.5.4.12 5-Hg-dCMP + H2O deamination activated by dTTP and inhibited by dCTP Equus asinus 5-Hg-dUMP + NH3
-
?
3.5.4.12 5-hydroxymethyl-dCMP + H2O
-
Gallus gallus 5-hydroxymethyl-dUMP + NH3
-
?
3.5.4.12 5-hydroxymethyl-dCMP + H2O
-
Tequatrovirus T4 5-hydroxymethyl-dUMP + NH3
-
?
3.5.4.12 5-hydroxymethyl-dCMP + H2O
-
Equus asinus 5-hydroxymethyl-dUMP + NH3
-
?
3.5.4.12 5-hydroxymethyl-dCMP + H2O HeLa cells, good substrate Homo sapiens 5-hydroxymethyl-dUMP + NH3
-
?
3.5.4.12 5-iodo-dCMP + H2O
-
Gallus gallus 5-iodo-dUMP + NH3
-
?
3.5.4.12 5-iodo-dCMP + H2O
-
Equus asinus 5-iodo-dUMP + NH3
-
?
3.5.4.12 5-iodo-dCMP + H2O very poor substrate Saccharomyces cerevisiae 5-iodo-dUMP + NH3
-
?
3.5.4.12 5-iodo-dCMP + H2O very poor substrate Escherichia phage T2 5-iodo-dUMP + NH3
-
?
3.5.4.12 5-methyl-dCMP + H2O
-
Homo sapiens 5-methyl-dUMP + NH3
-
?
3.5.4.12 5-methyl-dCMP + H2O
-
Saccharomyces cerevisiae 5-methyl-dUMP + NH3
-
?
3.5.4.12 5-methyl-dCMP + H2O
-
Equus asinus 5-methyl-dUMP + NH3
-
?
3.5.4.12 5-methyl-dCMP + H2O very good substrate Gallus gallus 5-methyl-dUMP + NH3
-
?
3.5.4.12 5-methyl-dCMP + H2O very good substrate Escherichia phage T2 5-methyl-dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Bacillus subtilis dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Homo sapiens dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Rattus norvegicus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Saccharomyces cerevisiae dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Tequatrovirus T4 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Echinoidea dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Equus asinus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Herpes simplex virus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Escherichia phage T2 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Betapolyomavirus macacae dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Enterobacteria phage T6 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Polyomavirus sp. dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Bacillus subtilis dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Homo sapiens dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Rattus norvegicus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Saccharomyces cerevisiae dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Tequatrovirus T4 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Echinoidea dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Equus asinus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Herpes simplex virus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Escherichia phage T2 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Betapolyomavirus macacae dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Enterobacteria phage T6 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA Polyomavirus sp. dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Bacillus subtilis dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Homo sapiens dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Rattus norvegicus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Saccharomyces cerevisiae dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Tequatrovirus T4 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Echinoidea dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Equus asinus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Herpes simplex virus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Escherichia phage T2 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Betapolyomavirus macacae dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Enterobacteria phage T6 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides Polyomavirus sp. dUMP + NH3
-
?
3.5.4.12 additional information
-
Homo sapiens ?
-
?
3.5.4.12 additional information substrate specificity Gallus gallus ?
-
?
3.5.4.12 additional information substrate specificity Bacillus subtilis ?
-
?
3.5.4.12 additional information substrate specificity Homo sapiens ?
-
?
3.5.4.12 additional information substrate specificity Saccharomyces cerevisiae ?
-
?
3.5.4.12 additional information substrate specificity Equus asinus ?
-
?
3.5.4.12 additional information substrate specificity Escherichia phage T2 ?
-
?
3.5.4.12 additional information function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants Tequatrovirus T4 ?
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.12 hexamer 6 identical subunits Gallus gallus
3.5.4.12 hexamer 6 identical subunits Homo sapiens
3.5.4.12 hexamer 6 identical subunits Rattus norvegicus
3.5.4.12 hexamer 6 identical subunits Tequatrovirus T4
3.5.4.12 hexamer 6 identical subunits Equus asinus
3.5.4.12 hexamer 6 identical subunits Escherichia phage T2
3.5.4.12 hexamer 6 identical subunits Enterobacteria phage T6
3.5.4.12 hexamer 6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.12 30
-
-
Tequatrovirus T4
3.5.4.12 30
-
optimum condition Homo sapiens