EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.5.4.12 | 3,4,5,6-tetrahydro-2'-dUMP | high-affinity inhibitor, rapid, reversible inhibition, kinetics of inhibition. At low substrate or competitor concentrations: activation. Tetrahydro-dUMP activates enzyme at low substrate concentrations | Equus asinus | |
3.5.4.12 | dCTP | positive allosteric effector | Equus asinus |
EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.4.12 | pharmacology | might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents | Equus asinus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.4.12 | 3,4,5,6-tetrahydro-2'-deoxyuridine | - |
Equus asinus | |
3.5.4.12 | 3,4,5,6-tetrahydro-2'-dUMP | high-affinity inhibitor, rapid, reversible inhibition, kinetics of inhibition. At low substrate or competitor concentrations: activation. Tetrahydro-dUMP activates enzyme at low substrate concentrations | Equus asinus | |
3.5.4.12 | additional information | kinetics of inhibition; mechanism of inhibition | Equus asinus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.4.12 | additional information | - |
additional information | kinetics of inhibition | Equus asinus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.12 | dCMP + H2O | Equus asinus | - |
dUMP + NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.4.12 | Equus asinus | - |
donkey | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.4.12 | - |
Equus asinus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.5.4.12 | dCMP + H2O = dUMP + NH3 | mechanism | Equus asinus | |
3.5.4.12 | dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Equus asinus | |
3.5.4.12 | dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Equus asinus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.4.12 | spleen | - |
Equus asinus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.12 | dCMP + H2O | - |
Equus asinus | dUMP + NH3 | - |
? |