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Literature summary extracted from

  • Maley, F.; Belfort, M.; Maley, G.
    Probing the infra-structure of thymidylate synthase and deoxycytidylate deaminase (1984), Adv. Enzyme Regul., 22, 413-430.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.12 5-hydroxymethyl-dCTP natural positive allosteric effector, enzyme is much more effectively regulated by its natural effector, 5-hydroxymethyl-dCTP, than by dCTP, binding of 5-hydroxymethyl-dCTP is much more pH dependent than dCTP Escherichia phage T2
3.5.4.12 dCTP positive allosteric effector Gallus gallus
3.5.4.12 dCTP positive allosteric effector Escherichia phage T2

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.5.4.12
-
Escherichia phage T2

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.12 additional information
-
additional information
-
Gallus gallus
3.5.4.12 additional information
-
additional information
-
Escherichia phage T2

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Gallus gallus enzyme involved in formation of dTMP dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Escherichia phage T2 enzyme involved in formation of dTMP dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Gallus gallus enzyme within pyrimidine deoxynucleotide pathway dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Escherichia phage T2 enzyme within pyrimidine deoxynucleotide pathway dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Gallus gallus enzyme plays an important if not rate controlling step in cell division dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Escherichia phage T2 enzyme plays an important if not rate controlling step in cell division dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Gallus gallus regulating dTMP for DNA synthesis dUMP + NH3
-
?
3.5.4.12 dCMP + H2O Escherichia phage T2 regulating dTMP for DNA synthesis dUMP + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.12 Escherichia phage T2
-
T2-phage infected Escherichia coli
-
3.5.4.12 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.12 T2-phage infected Escherichia coli Escherichia phage T2

Reaction

EC Number Reaction Comment Organism Reaction ID
3.5.4.12 dCMP + H2O = dUMP + NH3 mechanism Escherichia phage T2
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Gallus gallus
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Escherichia phage T2

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.12 embryo
-
Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.12 dCMP + H2O
-
Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O
-
Escherichia phage T2 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O enzyme involved in formation of dTMP Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O enzyme involved in formation of dTMP Escherichia phage T2 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O enzyme within pyrimidine deoxynucleotide pathway Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O enzyme within pyrimidine deoxynucleotide pathway Escherichia phage T2 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O enzyme plays an important if not rate controlling step in cell division Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O enzyme plays an important if not rate controlling step in cell division Escherichia phage T2 dUMP + NH3
-
?
3.5.4.12 dCMP + H2O regulating dTMP for DNA synthesis Gallus gallus dUMP + NH3
-
?
3.5.4.12 dCMP + H2O regulating dTMP for DNA synthesis Escherichia phage T2 dUMP + NH3
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.12 hexamer 6 identical subunits Gallus gallus
3.5.4.12 hexamer 6 identical subunits Escherichia phage T2

Synonyms

EC Number Synonyms Comment Organism
3.5.4.12 T2-dCMP deaminase T2-phage infected Escherichia phage T2
3.5.4.12 T2-deoxycytidylate deaminase T2-phage infected Escherichia phage T2
3.5.4.12 T2-phage deoxycytidylate deaminase T2-phage infected Escherichia phage T2