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Literature summary extracted from

  • Doering, T.L.; Masterson, W.J.; Englund, P.T.; Hart, G.W.
    Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine (1989), J. Biol. Chem., 264, 11168-11173.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.198 membrane
-
 Trypanosoma brucei 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol Trypanosoma brucei involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
3.5.1.89 N-Acetyl-D-glucosaminylphosphatidylinositol + H2O Trypanosoma sp. involved in the formation of the glycosylphosphatidylinositol membrane anchor of the trypanosome variant-surface glycoprotein ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.198 Trypanosoma brucei
-
 cloned variant ILTat 1.3, isolated from rat blood
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3.5.1.89 Trypanosoma sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol
-
 Trypanosoma brucei UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
2.4.1.198 UDP-N-acetyl-D-glucosamine + phosphatidylinositol involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins Trypanosoma brucei UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol
-
 ?
3.5.1.89 N-Acetyl-D-glucosaminylphosphatidylinositol + H2O
-
 Trypanosoma sp. D-Glucosaminylphosphatidylinositol + acetate
-
 ?
3.5.1.89 N-Acetyl-D-glucosaminylphosphatidylinositol + H2O involved in the formation of the glycosylphosphatidylinositol membrane anchor of the trypanosome variant-surface glycoprotein Trypanosoma sp. ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.198 7.4
-
 assay at Trypanosoma brucei