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Literature summary extracted from
- CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4 (1995), Arch. Biochem. Biophys., 319, 157-167.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.6.2.4 | coexpression with CYP3A4 in Spodoptera frugiperda and Trichoplusia ni cell lines | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.6.2.4 | microsome | - |
Homo sapiens | - |
- |
| 1.6.2.4 | microsome | - |
Trichoplusia ni | - |
- |
| 1.6.2.4 | microsome | - |
Spodoptera frugiperda | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.6.2.4 | Homo sapiens | - |
- |
- |
| 1.6.2.4 | Spodoptera frugiperda | - |
- |
- |
| 1.6.2.4 | Trichoplusia ni | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.6.2.4 | liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.6.2.4 | 0.0128 | - |
endogenous enzyme | Spodoptera frugiperda |
| 1.6.2.4 | 0.0173 | - |
endogenous enzyme | Trichoplusia ni |
| 1.6.2.4 | 0.225 | 0.38 | endogenous enzyme | Homo sapiens |
| 1.6.2.4 | 1.696 | - |
recombinant enzyme coexpressed with CYP3A4 in Spodoptera frugiperda cell lines | Homo sapiens |
| 1.6.2.4 | 3.904 | - |
recombinant enzyme coexpressed with CYP3A4 in Trichoplusia ni cell lines | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.6.2.4 | 2 ferricytochrome c + NADPH | - |
Homo sapiens | 2 ferrocytochrome c + NADP+ + H+ | - |
? |  |
| 1.6.2.4 | 2 ferricytochrome c + NADPH | - |
Trichoplusia ni | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
| 1.6.2.4 | 2 ferricytochrome c + NADPH | - |
Spodoptera frugiperda | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
| 1.6.2.4 | additional information | coexpressed with CYP3A4 in insect cell lines, testosterone 6-beta-hydroxylase activity | Homo sapiens | ? | - |
? | |
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