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Literature summary extracted from

  • Takahashi, N.; Saito, T.; Goda, Y.; Tomita, K.
    Characterization of microsomal NADPH-dependent aldehyde reductase from rat brain (1986), J. Biochem., 99, 513-519.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.4 steapsin brain Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.03
-
hexadecanal
-
Rattus norvegicus
1.1.1.2 0.21
-
octanal
-
Rattus norvegicus
1.1.1.2 0.31
-
p-nitrobenzaldehyde
-
Rattus norvegicus
1.1.1.2 1.4
-
4-Nitroacetophenone
-
Rattus norvegicus
1.1.1.2 2.5
-
Benzalacetone
-
Rattus norvegicus
1.6.2.4 0.03
-
hexadecanal
-
Rattus norvegicus
1.6.2.4 0.21
-
octanal
-
Rattus norvegicus
1.6.2.4 0.31
-
4-nitrobenzaldehyde
-
Rattus norvegicus
1.6.2.4 1.4
-
4-Nitroacetophenone
-
Rattus norvegicus
1.6.2.4 2.5
-
Benzalacetone
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 cytosol
-
Rattus norvegicus 5829
-
1.6.2.4 microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 75000
-
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Rattus norvegicus
-
-
-
1.6.2.4 Rattus norvegicus
-
Wistar strain
-
1.6.2.4 Rattus norvegicus Wistar
-
Wistar strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
Rattus norvegicus
1.6.2.4
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
Rattus norvegicus
-
1.1.1.2 kidney
-
Rattus norvegicus
-
1.1.1.2 liver
-
Rattus norvegicus
-
1.6.2.4 brain
-
Rattus norvegicus
-
1.6.2.4 liver phenobarbital-treated animals Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 20
-
p-nitrobenzaldehyde as substrate Rattus norvegicus
1.1.1.2 211
-
hexadecanal as substrate Rattus norvegicus
1.6.2.4 0.02
-
brain Rattus norvegicus
1.6.2.4 0.211
-
brain, electron acceptor: hexadecanal Rattus norvegicus
1.6.2.4 5.9
-
brain, electron acceptor: p-nitrobenzaldehyde Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.6.2.4 -80°C Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 4-nitroacetophenone + NADPH + H+
-
Rattus norvegicus 1-(4-nitrophenyl)ethanol + NADP+
-
r
1.1.1.2 4-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus 4-pyridinemethanol + NADP+
-
r
1.1.1.2 4-pyridinecarboxaldehyde + NADPH
-
Rattus norvegicus Wistar 4-pyridinemethanol + NADP+
-
r
1.1.1.2 benzalacetone + NADPH
-
Rattus norvegicus ? + NADP+
-
?
1.1.1.2 additional information enzyme from rat brain microsomes do not reduce p-pyridinecarboxaldehyde, which is a very active substrate for high-Km aldehyde reductase from rat kidney cytosol Rattus norvegicus ?
-
?
1.1.1.2 additional information enzyme from rat brain microsomes do not reduce p-pyridinecarboxaldehyde, which is a very active substrate for high-Km aldehyde reductase from rat kidney cytosol Rattus norvegicus Wistar ?
-
?
1.1.1.2 n-hexadecanal + NADPH + H+
-
Rattus norvegicus n-hexadecanol + NADP+
-
r
1.1.1.2 n-hexadecanal + NADPH + H+
-
Rattus norvegicus Wistar n-hexadecanol + NADP+
-
r
1.1.1.2 n-octadecanal + NADPH + H+
-
Rattus norvegicus n-octadecanol + NADP+
-
r
1.1.1.2 n-octanal + NADPH + H+
-
Rattus norvegicus n-octanol + NADP+
-
?
1.1.1.2 n-octanal + NADPH + H+
-
Rattus norvegicus Wistar n-octanol + NADP+
-
?
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
Rattus norvegicus Wistar p-nitrobenzylalcohol + NADP+
-
r
1.6.2.4 2 ferricytochrome c + NADPH
-
Rattus norvegicus 2 ferrocytochrome c + NADP+ + H+
-
?
1.6.2.4 NADPH + H+ + 4-nitroacetophenone
-
Rattus norvegicus ?
-
r
1.6.2.4 NADPH + H+ + 4-nitrobenzaldehyde
-
Rattus norvegicus ?
-
r
1.6.2.4 NADPH + H+ + benzalacetone
-
Rattus norvegicus ?
-
r
1.6.2.4 NADPH + hexadecanal brain, hexadecanal replaceable by p-nitroacetophenone, or p-pyridinecarboxaldehyde, benzalacetone or p-nitrobenzaldehyde Rattus norvegicus NADP+ + hexadecanol
-
?
1.6.2.4 NADPH + octanal
-
Rattus norvegicus NADP+ + octanol
-
?

Subunits

EC Number Subunits Comment Organism
1.6.2.4 ? x * 75000-76000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 NADPH-cytochrome c reductase
-
Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.6.2.4 60
-
brain, inactivation Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.4 NADPH
-
Rattus norvegicus