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Literature summary extracted from

  • Rodwell, V.W.
    delta1-piperideine-6-carboxylic acid and alpha-aminoadipic acid delta-semialdehyde (1971), Methods Enzymol., 17B, 188-199.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.31 ATP 30% inhibition at 1 mM Pseudomonas putida
1.2.1.31 carbonyl reagents e.g.: hydroxylamine, KCN, in the presence of substrate Pseudomonas putida
1.2.1.31 HSO3- in presence of substrate Pseudomonas putida
1.2.1.31 hydroxylamine in presence of substrate Pseudomonas putida
1.2.1.31 KCN in presence of substrate Pseudomonas putida

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.31 0.002
-
 DELTA1-piperidine 6-carboxylate
-
 Pseudomonas putida

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.31 additional information no metal cofactor required Pseudomonas putida

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.31 L-2-aminoadipate-semialdehyde + NAD+ Pseudomonas putida degradative enzyme L-2-aminoadipate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.31 Pseudomonas putida
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.31 using protamine sulfate treatment, ammonium sulfate fractionation and treatment with calcium phosphate gel Pseudomonas putida

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.31 4.9
-
 after purification, gel fraction Pseudomonas putida

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.31 (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O
-
 Pseudomonas putida L-2-aminoadipate + NADH
-
 ir
1.2.1.31 DELTA1-piperidine 6-carboxylate + NAD+ + H2O
-
 Pseudomonas putida L-alpha-aminoadipate + NADH + H+
-
 r
1.2.1.31 L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
-
 Pseudomonas putida L-2-aminoadipate + NADH
-
 ir
1.2.1.31 L-2-aminoadipate-semialdehyde + NAD+ degradative enzyme Pseudomonas putida L-2-aminoadipate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.31 8.1
-
 L-alpha-aminoadipate-semialdehyde reduction Pseudomonas putida

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.31 NAD+
-
 Pseudomonas putida