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Literature summary extracted from

  • Rivett, A.J.; Tipton, K.F.
    Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase (1981), Eur. J. Biochem., 117, 187-193.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.24 4-hydroxybenzaldehyde
-
 Rattus norvegicus
1.2.1.24 acetaldehyde above 1 mM Rattus norvegicus
1.2.1.24 AMP 5'-AMP Rattus norvegicus
1.2.1.24 NADH competitive with respect to NAD+; mixed with respect to succinate semialdehyde Rattus norvegicus
1.2.1.24 succinate semialdehyde substrate inhibition, uncompetitive with respect to NAD+ Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.24 0.0025
-
 NAD+
-
 Rattus norvegicus
1.2.1.24 0.0027 0.0029 succinate semialdehyde
-
 Rattus norvegicus
1.2.1.24 0.03
-
 NAD+
-
 Rattus norvegicus
1.2.1.24 0.05
-
 3-acetylpyridine adenine dinucleotide
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.24
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.24 succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ compulsory-order mechanism, NAD+ is the first substrate to bind to the enzyme and NADH is the last product to dissociate from it Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.24 2.12
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.2.1.24 -20°C, in presence of 10% v/v glycerol, stable for several months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 succinate semialdehyde + 3-acetylpyridine adenine dinucleotide + H2O
-
 Rattus norvegicus succinate + reduced 3-acetylpyridine adenine dinucleotide + H+
-
 r
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
 Rattus norvegicus succinate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.24 8.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.24 7 10 pH 7.0: about 40% of maximal activity, pH 10.0: about 35% of maximal activity Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.24 3-acetylpyridine adenine dinucleotide
-
 Rattus norvegicus
1.2.1.24 NAD+
-
 Rattus norvegicus