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Literature summary extracted from

  • Monder, C.
    alpha-Keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate (1967), J. Biol. Chem., 242, 4603-4609.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.23 barbiturates
-
Ovis aries
1.2.1.23 cyanide
-
Ovis aries
1.2.1.23 glycine buffer complete blockage of the reaction Ovis aries
1.2.1.23 hydrazine 1-3 mM Ovis aries
1.2.1.23 hydroxylamine 1-3 mM Ovis aries
1.2.1.23 N-ethylmaleimide 3 mM Ovis aries
1.2.1.23 N-tris(hydroxymethyl)methylglycine
-
Ovis aries
1.2.1.23 p-chloromercuribenzoate
-
Ovis aries
1.2.1.23 p-hydroxymercuribenzoate 1-3 mM Ovis aries
1.2.1.23 Semicarbazide 1-3 mM Ovis aries
1.2.1.23 Sodium bisulfite 1 mM Ovis aries
1.2.1.49 barbiturates
-
Ovis aries
1.2.1.49 glycine buffer complete blockage of the reaction Ovis aries
1.2.1.49 hydrazine 1-3 mM Ovis aries
1.2.1.49 N-ethylmaleimide 1-3 mM Ovis aries
1.2.1.49 N-tris(hydroxymethyl)methylglycine
-
Ovis aries
1.2.1.49 p-hydroxymercuribenzoate 1-3 mM Ovis aries
1.2.1.49 Sodium bisulfite 1 mM Ovis aries
1.2.1.49 Sodium cyanide 1 mM Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.49 0.033
-
NADP+
-
Ovis aries
1.2.1.49 0.21
-
methylglyoxal
-
Ovis aries
1.2.1.49 0.21 0.83 methylglyoxal
-
Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.23 methylglyoxal + NAD+ + H2O Ovis aries ir pyruvate + NADH + H+
-
?
1.2.1.23 methylglyoxal + NAD+ + H2O Ovis aries i.e. pyruvaldehyde pyruvate + NADH + H+
-
?
1.2.1.49 methylglyoxal + NADP+ + H2O Ovis aries ir pyruvate + NADPH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.23 Ovis aries
-
-
-
1.2.1.49 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.23 using acetone powder extract, ammonium sulfate fractionation, alumina C-gamma gel and column chromatography on Sephadex G-200 Ovis aries
1.2.1.49 using acetone powder extract, ammonium sulfate fractionation, alumina C-gamma gel and column chromatography on Sephadex G-200 Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.23 adrenal gland
-
Ovis aries
-
1.2.1.23 kidney
-
Ovis aries
-
1.2.1.23 liver
-
Ovis aries
-
1.2.1.23 lung
-
Ovis aries
-
1.2.1.49 adrenal gland
-
Ovis aries
-
1.2.1.49 liver
-
Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.23 0.571
-
-
Ovis aries
1.2.1.49 0.23
-
-
Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.23 2-oxoaldehydes + NAD+ + H2O enzyme from sheep or rat liver also active with NADP+, see also EC 1.2.1.49 Ovis aries 2-oxo acids + NADH
-
?
1.2.1.23 methylglyoxal + NAD+ + H2O ir Ovis aries pyruvate + NADH + H+
-
?
1.2.1.23 methylglyoxal + NAD+ + H2O i.e. pyruvaldehyde Ovis aries pyruvate + NADH + H+
-
?
1.2.1.49 2-oxoaldehydes + NADP+ + H2O enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23 Ovis aries 2-oxo acids + NADPH
-
?
1.2.1.49 methylglyoxal + NADP+ + H2O ir Ovis aries pyruvate + NADPH + H+
-
?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.23 6.5
-
not active below Ovis aries
1.2.1.23 9.4
-
activity increases up to, Tris buffer Ovis aries
1.2.1.23 10.5
-
activity increases up to, carbonate buffer Ovis aries
1.2.1.49 6.5
-
not active below Ovis aries
1.2.1.49 9.4
-
activity increases up to, Tris buffer Ovis aries
1.2.1.49 10.5
-
activity increases up to, carbonate buffer Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.23 additional information 3-acetyl-pyridine adenine dinucleotide and thionicotinamide adenine dinucleotide are also effective oxidants Ovis aries
1.2.1.23 NAD+
-
Ovis aries
1.2.1.23 NADP+ enzyme from sheep or rat liver, see also EC 1.2.1.49 Ovis aries
1.2.1.49 additional information 3-acetyl-pyridine adenine dinucleotide and thionicotinamide adenine dinucleotide are also effective oxidants Ovis aries
1.2.1.49 NAD+ enzyme from sheep or rat liver, see also EC 1.2.1.23 Ovis aries
1.2.1.49 NADP+
-
Ovis aries