EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.23 | barbiturates | - |
Ovis aries | |
1.2.1.23 | cyanide | - |
Ovis aries | |
1.2.1.23 | glycine buffer | complete blockage of the reaction | Ovis aries | |
1.2.1.23 | hydrazine | 1-3 mM | Ovis aries | |
1.2.1.23 | hydroxylamine | 1-3 mM | Ovis aries | |
1.2.1.23 | N-ethylmaleimide | 3 mM | Ovis aries | |
1.2.1.23 | N-tris(hydroxymethyl)methylglycine | - |
Ovis aries | |
1.2.1.23 | p-chloromercuribenzoate | - |
Ovis aries | |
1.2.1.23 | p-hydroxymercuribenzoate | 1-3 mM | Ovis aries | |
1.2.1.23 | Semicarbazide | 1-3 mM | Ovis aries | |
1.2.1.23 | Sodium bisulfite | 1 mM | Ovis aries | |
1.2.1.49 | barbiturates | - |
Ovis aries | |
1.2.1.49 | glycine buffer | complete blockage of the reaction | Ovis aries | |
1.2.1.49 | hydrazine | 1-3 mM | Ovis aries | |
1.2.1.49 | N-ethylmaleimide | 1-3 mM | Ovis aries | |
1.2.1.49 | N-tris(hydroxymethyl)methylglycine | - |
Ovis aries | |
1.2.1.49 | p-hydroxymercuribenzoate | 1-3 mM | Ovis aries | |
1.2.1.49 | Sodium bisulfite | 1 mM | Ovis aries | |
1.2.1.49 | Sodium cyanide | 1 mM | Ovis aries |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.49 | 0.033 | - |
NADP+ | - |
Ovis aries | |
1.2.1.49 | 0.21 | - |
methylglyoxal | - |
Ovis aries | |
1.2.1.49 | 0.21 | 0.83 | methylglyoxal | - |
Ovis aries |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.23 | methylglyoxal + NAD+ + H2O | Ovis aries | ir | pyruvate + NADH + H+ | - |
? | |
1.2.1.23 | methylglyoxal + NAD+ + H2O | Ovis aries | i.e. pyruvaldehyde | pyruvate + NADH + H+ | - |
? | |
1.2.1.49 | methylglyoxal + NADP+ + H2O | Ovis aries | ir | pyruvate + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.23 | Ovis aries | - |
- |
- |
1.2.1.49 | Ovis aries | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.23 | using acetone powder extract, ammonium sulfate fractionation, alumina C-gamma gel and column chromatography on Sephadex G-200 | Ovis aries |
1.2.1.49 | using acetone powder extract, ammonium sulfate fractionation, alumina C-gamma gel and column chromatography on Sephadex G-200 | Ovis aries |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.23 | adrenal gland | - |
Ovis aries | - |
1.2.1.23 | kidney | - |
Ovis aries | - |
1.2.1.23 | liver | - |
Ovis aries | - |
1.2.1.23 | lung | - |
Ovis aries | - |
1.2.1.49 | adrenal gland | - |
Ovis aries | - |
1.2.1.49 | liver | - |
Ovis aries | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.23 | 0.571 | - |
- |
Ovis aries |
1.2.1.49 | 0.23 | - |
- |
Ovis aries |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.23 | 2-oxoaldehydes + NAD+ + H2O | enzyme from sheep or rat liver also active with NADP+, see also EC 1.2.1.49 | Ovis aries | 2-oxo acids + NADH | - |
? | |
1.2.1.23 | methylglyoxal + NAD+ + H2O | ir | Ovis aries | pyruvate + NADH + H+ | - |
? | |
1.2.1.23 | methylglyoxal + NAD+ + H2O | i.e. pyruvaldehyde | Ovis aries | pyruvate + NADH + H+ | - |
? | |
1.2.1.49 | 2-oxoaldehydes + NADP+ + H2O | enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23 | Ovis aries | 2-oxo acids + NADPH | - |
? | |
1.2.1.49 | methylglyoxal + NADP+ + H2O | ir | Ovis aries | pyruvate + NADPH + H+ | - |
? |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.23 | 6.5 | - |
not active below | Ovis aries |
1.2.1.23 | 9.4 | - |
activity increases up to, Tris buffer | Ovis aries |
1.2.1.23 | 10.5 | - |
activity increases up to, carbonate buffer | Ovis aries |
1.2.1.49 | 6.5 | - |
not active below | Ovis aries |
1.2.1.49 | 9.4 | - |
activity increases up to, Tris buffer | Ovis aries |
1.2.1.49 | 10.5 | - |
activity increases up to, carbonate buffer | Ovis aries |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.23 | additional information | 3-acetyl-pyridine adenine dinucleotide and thionicotinamide adenine dinucleotide are also effective oxidants | Ovis aries | |
1.2.1.23 | NAD+ | - |
Ovis aries | |
1.2.1.23 | NADP+ | enzyme from sheep or rat liver, see also EC 1.2.1.49 | Ovis aries | |
1.2.1.49 | additional information | 3-acetyl-pyridine adenine dinucleotide and thionicotinamide adenine dinucleotide are also effective oxidants | Ovis aries | |
1.2.1.49 | NAD+ | enzyme from sheep or rat liver, see also EC 1.2.1.23 | Ovis aries | |
1.2.1.49 | NADP+ | - |
Ovis aries |