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Literature summary extracted from

  • Testore, G.; Colombatto, S.; Silvagno, F.; Bedino, S.
    Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver (1995), Int. J. Biochem. Cell Biol., 27, 1201-1210.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.19 dithiothreitol 4-8 mM, full reactivation after inactivation due to overnight dialysis against 50 mM phosphate pH 7 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.19 acetaldehyde strongly inhibits 4-aminobutyraldehyde oxidation Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.19 0.003
-
capronaldehyde same value with benzaldehyde, constant substrate 1 mM NAD+ Rattus norvegicus
1.2.1.19 0.004
-
Valeraldehyde constant substrate 1 mM NAD+ Rattus norvegicus
1.2.1.19 0.005
-
Butyraldehyde constant substrate 1 mM NAD+ Rattus norvegicus
1.2.1.19 0.013
-
propionaldehyde constant substrate 1 mM NAD+ Rattus norvegicus
1.2.1.19 0.016
-
Isobutyraldehyde constant substrate 1 mM NAD+ Rattus norvegicus
1.2.1.19 0.07
-
NAD+ constant substrate 2 mM 4-aminobutyraldehyde Rattus norvegicus
1.2.1.19 0.109
-
4-Aminobutyraldehyde constant substrate 1 mM NAD+ Rattus norvegicus
1.2.1.19 0.111
-
acetaldehyde constant substrate 1 mM NAD+ Rattus norvegicus
1.2.1.19 0.186
-
NAD+ constant substrate 0.1 mM capronaldehyde Rattus norvegicus
1.2.1.19 0.256
-
NAD+ constant substrate 0.2 mM isotbutyraldehyde Rattus norvegicus
1.2.1.19 0.886
-
NAD+ constant substrate 2 mM acetaldehyde Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.19 cytoplasm
-
Rattus norvegicus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.19 Mg2+ 10% activation by 2 mM observed with 0.1 mM capronaldehyde as substrate Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.19 51000
-
2 * 51000, SDS-PAGE Rattus norvegicus
1.2.1.19 115000
-
gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.19 Rattus norvegicus
-
Wistar-strain
-
1.2.1.19 Rattus norvegicus Wistar-
-
Wistar-strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.19 using column chromatography on DEAE-cellulose, hydroxylapatite, Sephacryl S-300 and Phenyl-Superose and isoelectrofocusing Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.19 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.19 additional information
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.2.1.19 4°C, 250 mM phosphate, pH 6.8, in the presence of 4 mM dithiothreitol, activity decreases by 20-30% after 7 days, freezing resultes in complete inactivation Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.19 4-aminobutanal + NAD+ + H2O
-
Rattus norvegicus 4-aminobutanoate + NADH + H+
-
?
1.2.1.19 4-aminobutanal + NAD+ + H2O
-
Rattus norvegicus Wistar- 4-aminobutanoate + NADH + H+
-
?
1.2.1.19 acetaldehyde + NAD+ + H2O
-
Rattus norvegicus acetate + NADH + H+
-
?
1.2.1.19 benzaldehyde + NAD+ + H2O
-
Rattus norvegicus benzoate + NADH + H+
-
?
1.2.1.19 butyraldehyde + NAD+ + H2O
-
Rattus norvegicus butyrate + NADH + H+
-
?
1.2.1.19 butyraldehyde + NAD+ + H2O
-
Rattus norvegicus Wistar- butyrate + NADH + H+
-
?
1.2.1.19 capronaldehyde + NAD+ + H2O
-
Rattus norvegicus capronate + NADH + H+
-
?
1.2.1.19 capronaldehyde + NAD+ + H2O
-
Rattus norvegicus Wistar- capronate + NADH + H+
-
?
1.2.1.19 isobutyraldehyde + NAD+ + H2O
-
Rattus norvegicus isobutyrate + NADH + H+
-
?
1.2.1.19 propionaldehyde + NAD+ + H2O
-
Rattus norvegicus propionate + NADH + H+
-
?
1.2.1.19 propionaldehyde + NAD+ + H2O
-
Rattus norvegicus Wistar- propionate + NADH + H+
-
?
1.2.1.19 valeraldehyde + NAD+ + H2O
-
Rattus norvegicus valerate + NADH + H+
-
?
1.2.1.19 valeraldehyde + NAD+ + H2O
-
Rattus norvegicus Wistar- valerate + NADH + H+
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.19 dimer 2 * 51000, SDS-PAGE Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.19 28
-
temperature higher than 28°C promotes slow activation Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.19 7.3 8.4
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.19 NAD+
-
Rattus norvegicus