EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.19 | dithiothreitol | 4-8 mM, full reactivation after inactivation due to overnight dialysis against 50 mM phosphate pH 7 | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.19 | acetaldehyde | strongly inhibits 4-aminobutyraldehyde oxidation | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.19 | 0.003 | - |
capronaldehyde | same value with benzaldehyde, constant substrate 1 mM NAD+ | Rattus norvegicus | |
1.2.1.19 | 0.004 | - |
Valeraldehyde | constant substrate 1 mM NAD+ | Rattus norvegicus | |
1.2.1.19 | 0.005 | - |
Butyraldehyde | constant substrate 1 mM NAD+ | Rattus norvegicus | |
1.2.1.19 | 0.013 | - |
propionaldehyde | constant substrate 1 mM NAD+ | Rattus norvegicus | |
1.2.1.19 | 0.016 | - |
Isobutyraldehyde | constant substrate 1 mM NAD+ | Rattus norvegicus | |
1.2.1.19 | 0.07 | - |
NAD+ | constant substrate 2 mM 4-aminobutyraldehyde | Rattus norvegicus | |
1.2.1.19 | 0.109 | - |
4-Aminobutyraldehyde | constant substrate 1 mM NAD+ | Rattus norvegicus | |
1.2.1.19 | 0.111 | - |
acetaldehyde | constant substrate 1 mM NAD+ | Rattus norvegicus | |
1.2.1.19 | 0.186 | - |
NAD+ | constant substrate 0.1 mM capronaldehyde | Rattus norvegicus | |
1.2.1.19 | 0.256 | - |
NAD+ | constant substrate 0.2 mM isotbutyraldehyde | Rattus norvegicus | |
1.2.1.19 | 0.886 | - |
NAD+ | constant substrate 2 mM acetaldehyde | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.1.19 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.19 | Mg2+ | 10% activation by 2 mM observed with 0.1 mM capronaldehyde as substrate | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.19 | 51000 | - |
2 * 51000, SDS-PAGE | Rattus norvegicus |
1.2.1.19 | 115000 | - |
gel filtration | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.19 | Rattus norvegicus | - |
Wistar-strain | - |
1.2.1.19 | Rattus norvegicus Wistar- | - |
Wistar-strain | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.19 | using column chromatography on DEAE-cellulose, hydroxylapatite, Sephacryl S-300 and Phenyl-Superose and isoelectrofocusing | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.19 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.19 | additional information | - |
- |
Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
1.2.1.19 | 4°C, 250 mM phosphate, pH 6.8, in the presence of 4 mM dithiothreitol, activity decreases by 20-30% after 7 days, freezing resultes in complete inactivation | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.19 | 4-aminobutanal + NAD+ + H2O | - |
Rattus norvegicus | 4-aminobutanoate + NADH + H+ | - |
? | |
1.2.1.19 | 4-aminobutanal + NAD+ + H2O | - |
Rattus norvegicus Wistar- | 4-aminobutanoate + NADH + H+ | - |
? | |
1.2.1.19 | acetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | acetate + NADH + H+ | - |
? | |
1.2.1.19 | benzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | benzoate + NADH + H+ | - |
? | |
1.2.1.19 | butyraldehyde + NAD+ + H2O | - |
Rattus norvegicus | butyrate + NADH + H+ | - |
? | |
1.2.1.19 | butyraldehyde + NAD+ + H2O | - |
Rattus norvegicus Wistar- | butyrate + NADH + H+ | - |
? | |
1.2.1.19 | capronaldehyde + NAD+ + H2O | - |
Rattus norvegicus | capronate + NADH + H+ | - |
? | |
1.2.1.19 | capronaldehyde + NAD+ + H2O | - |
Rattus norvegicus Wistar- | capronate + NADH + H+ | - |
? | |
1.2.1.19 | isobutyraldehyde + NAD+ + H2O | - |
Rattus norvegicus | isobutyrate + NADH + H+ | - |
? | |
1.2.1.19 | propionaldehyde + NAD+ + H2O | - |
Rattus norvegicus | propionate + NADH + H+ | - |
? | |
1.2.1.19 | propionaldehyde + NAD+ + H2O | - |
Rattus norvegicus Wistar- | propionate + NADH + H+ | - |
? | |
1.2.1.19 | valeraldehyde + NAD+ + H2O | - |
Rattus norvegicus | valerate + NADH + H+ | - |
? | |
1.2.1.19 | valeraldehyde + NAD+ + H2O | - |
Rattus norvegicus Wistar- | valerate + NADH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.19 | dimer | 2 * 51000, SDS-PAGE | Rattus norvegicus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.19 | 28 | - |
temperature higher than 28°C promotes slow activation | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.19 | 7.3 | 8.4 | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.19 | NAD+ | - |
Rattus norvegicus |