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Literature summary extracted from

  • Tago, K.; Kurioka, S.; Matsuda, M.
    4-Aminobutyraldehyde dehydrogenase activity in rat brain (1982), J. Neurochem., 39, 803-809.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.19 0.083
-
 4-Aminobutyraldehyde
-
 Rattus norvegicus
1.2.1.19 0.48
-
 NAD+
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.19 cytoplasm
-
 Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.19 4-aminobutanal + NAD+ + H2O Rattus norvegicus synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain 4-aminobutanoate + NADH + H+
-
 ?
1.2.1.19 4-aminobutanal + NAD+ + H2O Rattus norvegicus Wistar- synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain 4-aminobutanoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.19 Rattus norvegicus
-
 Wistar-strain
-
1.2.1.19 Rattus norvegicus Wistar-
-
 Wistar-strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.19 using ammonium sulfate fractionation and column chromatography on DEAE-cellulose, AMP-Sepharose, Sephadex G-200 and NAD+-Sepharose Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.19 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.19 0.2
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.2.1.19 -20°C, several months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.19 3-aminopropanal + NAD+ + H2O 17% the rate of 4-aminobutyraldehyde reduction Rattus norvegicus 3-aminopropanoate + NADH + H+
-
 ?
1.2.1.19 3-aminopropanal + NAD+ + H2O 17% the rate of 4-aminobutyraldehyde reduction Rattus norvegicus Wistar- 3-aminopropanoate + NADH + H+
-
 ?
1.2.1.19 4-aminobutanal + NAD+ + H2O
-
 Rattus norvegicus 4-aminobutanoate + NADH + H+
-
 ?
1.2.1.19 4-aminobutanal + NAD+ + H2O synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain Rattus norvegicus 4-aminobutanoate + NADH + H+
-
 ?
1.2.1.19 4-aminobutanal + NAD+ + H2O
-
 Rattus norvegicus Wistar- 4-aminobutanoate + NADH + H+
-
 ?
1.2.1.19 4-aminobutanal + NAD+ + H2O synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid in brain Rattus norvegicus Wistar- 4-aminobutanoate + NADH + H+
-
 ?
1.2.1.19 additional information very low activity with: succinate semialdehyde Rattus norvegicus ?
-
 ?
1.2.1.19 additional information very low activity with benzaldehyde, propionaldehyde Rattus norvegicus ?
-
 ?
1.2.1.19 additional information very low activity with: succinate semialdehyde Rattus norvegicus Wistar- ?
-
 ?
1.2.1.19 additional information very low activity with benzaldehyde, propionaldehyde Rattus norvegicus Wistar- ?
-
 ?
1.2.1.19 succinate semialdehyde + NAD+ 24% the rate of 4-aminobutyraldehyde reduction Rattus norvegicus succinate + NADH + H+
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.19 -20
-
 stable over several months Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.19 8
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.19 6.9 8.5 at pH 6.9: about 30% of activity maximum, at pH 8.5: about 65% of activity maximum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.19 NAD+
-
 Rattus norvegicus