EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.18 | NADH | competitive with NAD+ | Rattus norvegicus | |
1.2.1.27 | NADH | competitive with NAD+ | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.18 | 0.0045 | - |
3-oxopropanoate | - |
Rattus norvegicus | |
1.2.1.18 | 0.0053 | - |
2-Methyl-3-oxopropanoate | - |
Rattus norvegicus | |
1.2.1.18 | 0.03 | - |
CoA | - |
Rattus norvegicus | |
1.2.1.18 | 0.15 | - |
NAD+ | - |
Rattus norvegicus | |
1.2.1.27 | 0.0045 | - |
malonate semialdehyde | - |
Rattus norvegicus | |
1.2.1.27 | 0.0053 | - |
2-Methyl-3-oxopropanoate | - |
Rattus norvegicus | |
1.2.1.27 | 0.03 | - |
CoA | - |
Rattus norvegicus | |
1.2.1.27 | 0.15 | - |
NAD+ | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.1.18 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.18 | 58000 | - |
4 * 58000, SDS-PAGE | Rattus norvegicus |
1.2.1.18 | 250000 | - |
gel filtration | Rattus norvegicus |
1.2.1.27 | 58000 | - |
4 * 58000, SDS-PAGE | Rattus norvegicus |
1.2.1.27 | 250000 | - |
gel filtration | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.27 | 2-methyl-3-oxopropanoate + CoA + NAD+ | Rattus norvegicus | - |
propanoyl-CoA + CO2 + NADH | - |
ir | |
1.2.1.27 | malonate semialdehyde + CoA + NAD+ | Rattus norvegicus | - |
acetyl-CoA + CO2 + NADH | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.18 | Rattus norvegicus | - |
- |
- |
1.2.1.27 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.18 | - |
Rattus norvegicus |
1.2.1.27 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.18 | liver | - |
Rattus norvegicus | - |
1.2.1.27 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.18 | 1.83 | - |
- |
Rattus norvegicus |
1.2.1.27 | 1.83 | - |
- |
Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
1.2.1.27 | on ice, 1 mM NAD+, 20 h, 77% activity remains | Rattus norvegicus |
1.2.1.27 | on ice, 10% glycerol, 20 h, 32% activity remains | Rattus norvegicus |
1.2.1.27 | on ice, 20 h, 11% activity remains | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.18 | 2-methyl-3-oxopropanoate + CoA + NAD+ | both stereoisomers | Rattus norvegicus | propanoyl-CoA + CO2 + NADH | - |
? | |
1.2.1.18 | 3-oxopropanoate + CoA + NAD+ | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
? | |
1.2.1.27 | 2-methyl-3-oxopropanoate + CoA + NAD+ | - |
Rattus norvegicus | propanoyl-CoA + CO2 + NADH | - |
ir | |
1.2.1.27 | 2-methyl-3-oxopropanoate + CoA + NAD+ | both stereoisomers are oxidized | Rattus norvegicus | propanoyl-CoA + CO2 + NADH | - |
ir | |
1.2.1.27 | 2-methylbutyraldehyde + CoA + NAD+ | low activity | Rattus norvegicus | ? | - |
? | |
1.2.1.27 | acetaldehyde + CoA + NAD+ | low activity | Rattus norvegicus | ? | - |
? | |
1.2.1.27 | butyraldehyde + CoA + NAD+ | low activity | Rattus norvegicus | ? | - |
? | |
1.2.1.27 | isobutyraldehyde + CoA + NAD+ | low activity | Rattus norvegicus | ? | - |
? | |
1.2.1.27 | malonate semialdehyde + CoA + NAD+ | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
ir | |
1.2.1.27 | malondialdehyde + CoA + NAD+ | low activity | Rattus norvegicus | ? | - |
? | |
1.2.1.27 | propanal + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
1.2.1.27 | succinate semialdehyde + CoA + NAD+ | very low activity | Rattus norvegicus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.18 | tetramer | 4 * 58000, SDS-PAGE | Rattus norvegicus |
1.2.1.27 | tetramer | 4 * 58000, SDS-PAGE | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.18 | 8 | - |
reaction with 2-methyl-3-oxopropanoate | Rattus norvegicus |
1.2.1.27 | 8 | - |
2-methyl-3-oxopropanoate + CoA + NAD+ | Rattus norvegicus |
1.2.1.27 | 9 | - |
propanal + NAD+ | Rattus norvegicus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.27 | 7 | 8.5 | methylmalonate semialdehyde oxidation, less than 90% of maximal activity above and below | Rattus norvegicus |
1.2.1.27 | 8 | 9.5 | propanal oxidation, less than 50% of maximal activity above and below | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.18 | NAD+ | cofactor | Rattus norvegicus | |
1.2.1.27 | CoA | - |
Rattus norvegicus | |
1.2.1.27 | NAD+ | - |
Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.27 | 0.0031 | - |
NADH | - |
Rattus norvegicus |