EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.284 | ADP | competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione | [Candida] boidinii | |
1.1.1.284 | AMP | competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione | [Candida] boidinii | |
1.1.1.284 | ATP | competitive with respect to NAD+, noncompetitive with respect to S-hydroxymethylglutathione | [Candida] boidinii | |
1.1.1.284 | NADH | - |
[Candida] boidinii | |
1.1.1.284 | S-formylglutathione | - |
[Candida] boidinii | |
1.1.1.284 | S-hydroxymethylglutathione | - |
[Candida] boidinii | |
1.17.1.9 | ADP | inhibition is greater at acidic pH than at neutral pH | [Candida] boidinii | |
1.17.1.9 | AMP | - |
[Candida] boidinii | |
1.17.1.9 | ATP | inhibition is greater at acidic pH than at neutral pH | [Candida] boidinii | |
1.17.1.9 | CO2 | - |
[Candida] boidinii | |
1.17.1.9 | NADH | competitive versus NAD+ | [Candida] boidinii | |
1.17.1.9 | NADPH | - |
[Candida] boidinii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.284 | formaldehyde + glutathione + NAD+ | [Candida] boidinii | key enzyme of the dissimilatory pathway of the methanol metabolism | S-formylglutathione + NADH + H+ | - |
? | |
1.17.1.9 | formate + NAD+ | [Candida] boidinii | last enzyme of the dissimilatory pathway of the methanol metabolism | CO2 + NADH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.284 | [Candida] boidinii | - |
- |
- |
1.17.1.9 | [Candida] boidinii | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.284 | S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ | ordered bi-bi mechanism | [Candida] boidinii | |
1.17.1.9 | formate + NAD+ = CO2 + NADH + H+ | ordered bi-bi mechanism, NAD+ is the first substrate and NADH is the last product | [Candida] boidinii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.284 | formaldehyde + glutathione + NAD+ | the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione | [Candida] boidinii | S-formylglutathione + NADH + H+ | - |
r | |
1.1.1.284 | formaldehyde + glutathione + NAD+ | key enzyme of the dissimilatory pathway of the methanol metabolism | [Candida] boidinii | S-formylglutathione + NADH + H+ | - |
? | |
1.1.1.284 | S-formylglutathione + NADH | - |
[Candida] boidinii | formaldehyde + glutathione + NAD+ | - |
r | |
1.17.1.9 | formate + NAD+ | - |
[Candida] boidinii | CO2 + NADH + H+ | - |
? | |
1.17.1.9 | formate + NAD+ | last enzyme of the dissimilatory pathway of the methanol metabolism | [Candida] boidinii | CO2 + NADH + H+ | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.284 | NAD+ | - |
[Candida] boidinii | |
1.1.1.284 | NADH | - |
[Candida] boidinii | |
1.17.1.9 | NAD+ | - |
[Candida] boidinii |