Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Uotila, L.; Mannervik, B.
    A steady-state-kinetic model for formaldehyde dehydrogenase from human liver. A mechanism involving NAD+ and the hemimercaptal adduct of glutathione and formaldehyde as substrates and free glutathione as an allosteric activator of the enzyme (1979), Biochem. J., 177, 869-878.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.284 ADP-ribose competitive with respect to beta-NAD+ and non-competitive with glutathione Homo sapiens
1.1.1.284 Alpha-NAD+ competitive with respect to beta-NAD+ and non-competitive with glutathione Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.284 0.0048
-
 beta-NAD+
-
 Homo sapiens
1.1.1.284 0.0301
-
 thio-NAD+
-
 Homo sapiens
1.1.1.284 0.0352
-
 nicotinamide-hypoxanthine dinucleotide
-
 Homo sapiens
1.1.1.284 0.0509
-
 3-acetylpyridine-adenine dinucleotide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.284 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.284 S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ random sequential mechanism Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.284 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.284 formaldehyde + glutathione + 3-acetylpyridine-adenine dinucleotide
-
 Homo sapiens S-formylglutathione + ?
-
 ?
1.1.1.284 formaldehyde + glutathione + NAD+
-
 Homo sapiens S-formylglutathione + NADH + H+
-
 ?
1.1.1.284 formaldehyde + glutathione + nicotinamide-hypoxanthine dinucleotide
-
 Homo sapiens S-formylglutathione + ?
-
 ?
1.1.1.284 formaldehyde + glutathione + thio-NAD+
-
 Homo sapiens S-formylglutathione + thio-NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.284 3-acetylpyridine adenine dinucleotide can substitute for beta-NAD+ Homo sapiens
1.1.1.284 NAD+
-
 Homo sapiens
1.1.1.284 nicotinamide hypoxanthine dinucleotide can substitute for beta-NAD+ Homo sapiens
1.1.1.284 thio-NAD+ can substitute for beta-NAD+ Homo sapiens