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Literature summary extracted from

  • Kohn, L.D.; Jakoby, W.B.
    Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase) (1968), J. Biol. Chem., 243, 2494-2499.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.81 Br- 2fold activation Delftia acidovorans
1.1.1.81 Cl- 2fold activation Delftia acidovorans
1.1.1.81 I- 2.5fold activation Delftia acidovorans
1.1.1.81 NO3- 2fold activation Delftia acidovorans
1.1.1.81 SO42- 2fold activation Delftia acidovorans

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.81 Sodium bisulfite 0.01 mM, 16% inhibition, 0.1 mM, 67% inhibition Delftia acidovorans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.81 0.015
-
 NADPH
-
 Delftia acidovorans
1.1.1.81 0.13
-
 Hydroxypyruvate with 0.15 mM NADPH Delftia acidovorans
1.1.1.81 0.24
-
 NADH
-
 Delftia acidovorans
1.1.1.81 2.1
-
 Hydroxypyruvate with 0.15 mM NADH Delftia acidovorans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.81 hydroxypyruvate + NAD(P)H Delftia acidovorans
-
 D-glycerate + NAD(P)+ + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.81 Delftia acidovorans
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.81 14.6
-
-
 Delftia acidovorans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.81 hydroxypyruvate + NAD(P)H
-
 Delftia acidovorans D-glycerate + NAD(P)+ + H+
-
 ?
1.1.1.81 hydroxypyruvate + NAD(P)H
-
 Delftia acidovorans D-glycerate + NAD(P)+ + H+
-
 r
1.1.1.81 hydroxypyruvate + NADH + H+
-
 Delftia acidovorans D-glycerate + NAD+
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.81 5.3
-
 sharp drop of activity below and above Delftia acidovorans

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.81 5.3
-
 sharp drop of activity below and above Delftia acidovorans