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Literature summary extracted from

  • Uhr, M.L.; Sneddon, M.K.
    Glycine and serine inhibition of D-glycerate dehydrogenase and 3-phosphoglycerate dehydrogenase of rat brain (1971), FEBS Lett., 17, 137-140.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.81 glycine
-
 Rattus norvegicus
1.1.1.81 serine
-
 Rattus norvegicus
1.1.1.95 glycine slightly Rattus norvegicus
1.1.1.95 L-serine non-linear and competitive Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.81 hydroxypyruvate + NAD(P)H Rattus norvegicus
-
 D-glycerate + NAD(P)+ + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.81 Rattus norvegicus
-
-
-
1.1.1.95 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.81 brain
-
 Rattus norvegicus
-
1.1.1.95 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.81 hydroxypyruvate + NAD(P)H
-
 Rattus norvegicus D-glycerate + NAD(P)+ + H+
-
 ?
1.1.1.95 3-phosphoglycerate + NAD+
-
 Rattus norvegicus 3-phosphohydroxypyruvate + NADH
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.95 NAD+
-
 Rattus norvegicus
1.1.1.95 NADH
-
 Rattus norvegicus