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Literature summary extracted from

  • Feld, R.D.; Sallach, H.J.
    Comparison of D-glycerate dehydrogenases from beef liver, beef spinal cord and hog spinal cord (1975), Arch. Biochem. Biophys., 166, 417-425.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.81 ATP 1 mM, 62% and 64% inhibition of liver and spinal cord enzyme respectively, 73% and 89% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively Bos taurus
1.1.1.81 CTP 1 mM, 73% and 71% inhibition of liver and spinal cord enzyme respectively Bos taurus
1.1.1.81 GTP 1 mM, 94% and 93% inhibition of liver and spinal cord enzyme respectively Bos taurus
1.1.1.81 phosphohydroxypyruvate 0.025 mM, 66% and 64% inhibition of liver and spinal cord enzyme respectively Bos taurus
1.1.1.81 UTP 1 mM, 83% and 84% inhibition of liver and spinal cord enzyme respectively Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.81 0.018
-
 NADPH
-
 Bos taurus
1.1.1.81 0.1
-
 Hydroxypyruvate
-
 Bos taurus
1.1.1.81 0.112
-
 NADH
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.81 hydroxypyruvate + NAD(P)H Sus scrofa
-
 D-glycerate + NAD(P)+ + H+
-
 ?
1.1.1.81 hydroxypyruvate + NAD(P)H Bos taurus
-
 D-glycerate + NAD(P)+ + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.81 Bos taurus
-
-
-
1.1.1.81 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.81 liver
-
 Bos taurus
-
1.1.1.81 spinal cord
-
 Sus scrofa
-
1.1.1.81 spinal cord
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.81 104.8
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.81 3-hydroxypyruvate + NADH + H+
-
 Bos taurus D-glycerate + NAD+
-
 r
1.1.1.81 hydroxypyruvate + NAD(P)H
-
 Sus scrofa D-glycerate + NAD(P)+ + H+
-
 ?
1.1.1.81 hydroxypyruvate + NAD(P)H
-
 Bos taurus D-glycerate + NAD(P)+ + H+
-
 ?