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Literature summary extracted from

  • Ting, S.M.; Sellinger, O.Z.; Miller, O.N.
    The metabolism of lactaldehyde VI. The reduction of D- and L-lactaldehyde in rat liver (1965), Biochim. Biophys. Acta, 89, 217-225.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.77 iodoacetate
-
 Rattus norvegicus
1.1.1.77 N-ethylmaleimide
-
 Rattus norvegicus
1.1.1.77 p-chloromercuribenzoate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.77 0.065
-
 acetaldehyde
-
 Rattus norvegicus
1.1.1.77 0.26
-
 ethanol
-
 Rattus norvegicus
1.1.1.77 0.56
-
 DL-lactaldehyde
-
 Rattus norvegicus
1.1.1.77 11
-
 DL-1,2-Propanediol
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.77 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.77 extraction, heat treatment, ammonium sulfate-fractionation, DEAE-cellulose and Alumina C Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.77 brain
-
 Rattus norvegicus
-
1.1.1.77 heart
-
 Rattus norvegicus
-
1.1.1.77 liver
-
 Rattus norvegicus
-
1.1.1.77 lung
-
 Rattus norvegicus
-
1.1.1.77 skeletal muscle
-
 Rattus norvegicus
-
1.1.1.77 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.77 (R)-propane-1,2-diol + NAD+ utilizes D- and L-lactaldehyde in the reverse direction equally well Rattus norvegicus (R)-lactaldehyde + NADH
-
 r
1.1.1.77 (S)-propane-1,2-diol + NAD+
-
 Rattus norvegicus (S)-lactaldehyde + NADH
-
 r
1.1.1.77 DL-1,2-propanediol + NAD+
-
 Rattus norvegicus DL-lactaldehyde + NADH + H+
-
 r
1.1.1.77 DL-lactaldehyde + NADH + H+
-
 Rattus norvegicus DL-1,2-propanediol + NAD+
-
 r
1.1.1.77 ethanol + NAD+
-
 Rattus norvegicus acetaldehyde + NADH
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.77 6.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.77 6 7.8 reduction of DL-lactaldehyde, pH 6: 50% of reductase activity maximum, pH 7.8: 45% of reductase activity maximum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.77 NAD+
-
 Rattus norvegicus
1.1.1.77 NADH
-
 Rattus norvegicus
1.1.1.77 NADP+ one tenth of the activity as with NAD+ Rattus norvegicus