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Literature summary extracted from
- Some properties of the pyridine nucleotide-specific 17beta-hydroxy steroid dehydrogenases of guinea pig liver (1960), J. Biol. Chem., 235, 3615-3619.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.64 | 0.011 | - |
NADP+ | - |
Cavia porcellus |  |
| 1.1.1.64 | 0.27 | - |
testosterone | - |
Cavia porcellus | |
| 1.1.1.239 | 0.033 | - |
testosterone | - |
Cavia porcellus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.64 | microsome | - |
Cavia porcellus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.64 | 17beta-estradiol + NADP+ | Cavia porcellus | - |
estrone + NADPH | - |
r | |
| 1.1.1.64 | testosterone + NADP+ | Cavia porcellus | - |
androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
| 1.1.1.239 | testosterone + NAD+ | Cavia porcellus | - |
androst-4-ene-3,17-dione + NADH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.64 | Cavia porcellus | - |
- |
- |
| 1.1.1.239 | Cavia porcellus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.64 | ammonium sulfate, calcium phosphate gel, starch electrophoresis | Cavia porcellus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.64 | liver | - |
Cavia porcellus | - |
| 1.1.1.239 | liver | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.64 | 145 | - |
- |
Cavia porcellus |
| 1.1.1.239 | 22.3 | - |
microsomal activitiy | Cavia porcellus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.64 | 17beta-estradiol + NADP+ | - |
Cavia porcellus | estrone + NADPH | - |
r | |
| 1.1.1.64 | testosterone + NADP+ | - |
Cavia porcellus | androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
| 1.1.1.239 | testosterone + NAD+ | - |
Cavia porcellus | androst-4-ene-3,17-dione + NADH + H+ | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.64 | 57 | - |
complete inactivation after 15 min | Cavia porcellus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.64 | NADP+ | - |
Cavia porcellus | |
| 1.1.1.239 | NAD+ | - |
Cavia porcellus | |
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Release 2023.1 (January 2023)
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