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Literature summary extracted from

  • Krazeisen, A.; Breitling, R.; M๖ller, G.; Adamski, J.
    Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5 (2001), Mol. Cell. Endocrinol., 171, 151-162.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.239 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.239 7-hydroxyflavone 0.007 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
1.1.1.239 abietic acid 0.010 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
1.1.1.239 biochain A 0.014 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.008 mM, oxidation of androstanediol Homo sapiens
1.1.1.239 chrysin 0.010 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
1.1.1.239 coumestrol 0.005 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.011 mM, 50% inhibition, oxidation of androstanediol Homo sapiens
1.1.1.239 kaempferol 0.008 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
1.1.1.239 naringenin 0.010 mM, 50% inhibition, oxidation of androstandiol Homo sapiens
1.1.1.239 quercetin 0.009 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.005 mM, oxidation of androstanediol Homo sapiens
1.1.1.239 zearalenone 0.004 mM, 50% inhibition, reduction of androst-4-ene-3,17-dione, 0.002 mM, oxidation of androstanediol Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.239 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.239 5alpha-dihydrotestosterone + NAD+ Homo sapiens
-
 androstandione + NADH + H+
-
 r
1.1.1.239 androstandiol + NAD+ Homo sapiens
-
 androsterone + NADH
-
 r
1.1.1.239 testosterone + NAD+ Homo sapiens
-
 androst-4-ene-3,17-dione + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.239 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.239 adrenal gland in males Homo sapiens
-
1.1.1.239 corpus luteum
-
 Homo sapiens
-
1.1.1.239 mammary gland
-
 Homo sapiens
-
1.1.1.239 testis expressed in Leydig cells Homo sapiens
-
1.1.1.239 uterine endometrium in females Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.239 5alpha-dihydrotestosterone + NAD+
-
 Homo sapiens androstanedione + NADH + H+
-
 r
1.1.1.239 5alpha-dihydrotestosterone + NAD+
-
 Homo sapiens androstandione + NADH + H+
-
 r
1.1.1.239 androstandiol + NAD+
-
 Homo sapiens androsterone + NADH
-
 r
1.1.1.239 androstanediol + NAD+
-
 Homo sapiens androsterone + NADH
-
 r
1.1.1.239 testosterone + NAD+
-
 Homo sapiens androst-4-ene-3,17-dione + NADH + H+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.239 NAD+
-
 Homo sapiens