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Literature summary extracted from

  • Ghosh, D.; Erman, M.; Wawrzak, Z.; Duax, W.L.; Pangborn, W.
    Mechanism of inhibition of 3alpha, 20beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor (1994), Curr. Biol., 2, 973-980.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.53 crystallized with bound inhibitor carbenoxolone, asymmetric tetramer, Tyr152, Lys156 and Ser139 are conserved as the catalytic triade Streptomyces exfoliatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.53 carbenoxolone
-
 Streptomyces exfoliatus
1.1.1.53 glycyrrhizic acid
-
 Streptomyces exfoliatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.53 3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H Streptomyces exfoliatus enzyme belongs to the group of short-chain dehydrogenases ?
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.53 Streptomyces exfoliatus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.53 3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H enzyme belongs to the group of short-chain dehydrogenases Streptomyces exfoliatus ?
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.53 More tetrameric, monomers with beta-alpha-beta-motif Streptomyces exfoliatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.53 NAD+
-
 Streptomyces exfoliatus
1.1.1.53 NADH
-
 Streptomyces exfoliatus