EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | iodoacetate | at 1 mM 100% inhibition of 17alpha-hydroxylation and 50% inhibition of lyase activity | Cavia porcellus | |
1.14.14.19 | nitrogen | complete inhibition | Cavia porcellus | |
1.14.14.19 | p-chloromercuribenzoate | at 1 mM complete inhibition | Cavia porcellus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.53 | cytosol | - |
Cavia porcellus | 5829 | - |
1.14.14.19 | microsome | membrane-bound | Cavia porcellus | - |
- |
1.14.14.19 | microsome | membrane-bound | Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Cavia porcellus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.53 | Cavia porcellus | - |
- |
- |
1.14.14.19 | Cavia porcellus | - |
- |
- |
1.14.14.19 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.19 | testis | - |
Cavia porcellus | - |
1.14.14.19 | testis | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Cavia porcellus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.53 | NADPH | - |
Cavia porcellus | |
1.14.14.19 | NADPH | - |
Cavia porcellus | |
1.14.14.19 | NADPH | - |
Rattus norvegicus |