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Literature summary extracted from

  • Berdis, A.J.; Cook, P.F.
    Overall kinetic mechanism of 6-phosphogluconate dehydrogenase from Candida utilis (1993), Biochemistry, 32, 2036-2040.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 D-ATP-ribose
-
 Cyberlindnera jadinii
1.1.1.44 NADPH noncompetitive inhibition versus 6-phosphogluconate Cyberlindnera jadinii
1.1.1.44 NADPH
-
 Homo sapiens
1.1.1.44 NADPH
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.002
-
 NADPH
-
 Cyberlindnera jadinii
1.1.1.44 0.008
-
 NADP+
-
 Cyberlindnera jadinii
1.1.1.44 0.22
-
 6-phosphogluconate
-
 Cyberlindnera jadinii
1.1.1.44 1
-
 ribulose-5-phosphate
-
 Cyberlindnera jadinii
1.1.1.44 50
-
 CO2
-
 Cyberlindnera jadinii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.44 cytoplasm
-
 Cyberlindnera jadinii 5737
-
1.1.1.44 cytoplasm
-
 Homo sapiens 5737
-
1.1.1.44 cytoplasm
-
 Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Haemophilus influenzae
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Rattus norvegicus
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Leuconostoc mesenteroides
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Cyberlindnera jadinii
-
-
-
1.1.1.44 Haemophilus influenzae
-
-
-
1.1.1.44 Homo sapiens
-
 human
-
1.1.1.44 Leuconostoc mesenteroides
-
-
-
1.1.1.44 Ovis aries
-
 sheep
-
1.1.1.44 Rattus norvegicus
-
 rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 erythrocyte
-
 Homo sapiens
-
1.1.1.44 erythrocyte
-
 Ovis aries
-
1.1.1.44 liver
-
 Homo sapiens
-
1.1.1.44 liver
-
 Rattus norvegicus
-
1.1.1.44 liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 48
-
-
 Cyberlindnera jadinii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Haemophilus influenzae D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Leuconostoc mesenteroides D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r