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Literature summary extracted from

  • Lessie, T.G.; Vander Wyk, J.C.
    Multiple forms of Pseudomonas multivorans glucose-6-phosphate and 6-phosphogluconate dehydrogenases: Differences in size, pyridine nucleotide specificity, and suspectibility to inhibition by adenosine 5'-triphosphate (1972), J. Bacteriol., 110, 1107-1117.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.43 NADPH
-
 Burkholderia cepacia

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.43 0.02
-
 6-phospho-D-gluconate isoform specific for NADP+ and isoform active with NAD+, with NADP+ as cofactor Burkholderia cepacia
1.1.1.43 0.04
-
 6-phospho-D-gluconate isoform specific for NADP+, with NADP+ as cofactor, glucose grown bacteria Burkholderia cepacia
1.1.1.43 0.04
-
 6-phospho-D-gluconate isoform specific for NADP+, with NADP+ as cofactor, 5 mM ATP, glucose grown bacteria Burkholderia cepacia
1.1.1.43 0.2
-
 6-phospho-D-gluconate isoform active with NAD+, NADP+ as cofactor, glucose grown bacteria Burkholderia cepacia
1.1.1.43 0.7
-
 6-phospho-D-gluconate isoform active with NAD as cofactor and isoform specific for NADP as cofactor, glucose grown bacteria Burkholderia cepacia
1.1.1.43 2
-
 6-phospho-D-gluconate isoform active with NAD+ as cofactor, 5 mM ATP, glucose grown bacteria Burkholderia cepacia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.43 6-phospho-D-gluconate + NAD(P)+ Enterococcus faecalis
-
 6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
 r
1.1.1.43 6-phospho-D-gluconate + NAD(P)+ Burkholderia cepacia
-
 6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.43 Burkholderia cepacia
-
 ATCC 17616, synonymous with Pseudomonas cepacia
-
1.1.1.43 Enterococcus faecalis
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.43 102
-
 coenzyme NAD+ Burkholderia cepacia
1.1.1.43 141
-
 coenzyme NADP+ Burkholderia cepacia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.43 6-phospho-D-gluconate + NAD(P)+
-
 Enterococcus faecalis 6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
 r
1.1.1.43 6-phospho-D-gluconate + NAD(P)+
-
 Burkholderia cepacia 6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.43 6-PGADHase
-
 Burkholderia cepacia

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.43 NAD+
-
 Burkholderia cepacia
1.1.1.43 NADP+
-
 Burkholderia cepacia