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Literature summary extracted from

  • Plaut, G.W.E.
    Isocitrate dehydrogenase (1963), The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 7, 105-126.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.41 AMP
-
Saccharomyces cerevisiae

General Stability

EC Number General Stability Organism
1.1.1.42 instable in solutions of low ionic strength, stabilization by ammonium sulfate Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.41 ATP
-
Bos taurus
1.1.1.41 CN-
-
Bos taurus
1.1.1.41 CN-
-
Pisum sativum
1.1.1.41 CN-
-
Saccharomyces cerevisiae
1.1.1.41 molybdate
-
Bos taurus
1.1.1.41 molybdate
-
Saccharomyces cerevisiae
1.1.1.41 N3-
-
Bos taurus
1.1.1.41 N3-
-
Saccharomyces cerevisiae
1.1.1.41 p-hydroxymercuribenzoate
-
Bos taurus
1.1.1.41 thiocyanate
-
Bos taurus
1.1.1.42 Ag+ decarboxylation of isocitrate and oxalosuccinate Sus scrofa
1.1.1.42 Cu2+
-
Sus scrofa
1.1.1.42 Diphenylchloroarsine
-
Sus scrofa
1.1.1.42 isocitrate competitive inhibition of decarboxylation of oxalosuccinate Sus scrofa
1.1.1.42 p-chloromercuribenzoate
-
Sus scrofa
1.1.1.42 p-hydroxymercuribenzoate decarboxylation of isocitrate and oxalosuccinate Sus scrofa
1.1.1.42 Phenarsazines
-
Sus scrofa
1.1.1.42 Phenylmercuric nitrate
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.41 0.11
-
D,L-isocitrate
-
Saccharomyces cerevisiae
1.1.1.41 0.45
-
D,L-isocitrate
-
Bos taurus
1.1.1.42 0.0026
-
D,L-isocitrate
-
Sus scrofa
1.1.1.42 0.0092
-
NADPH
-
Sus scrofa
1.1.1.42 0.13
-
2-oxoglutarate
-
Sus scrofa
1.1.1.42 0.56
-
oxalosuccinate reductase Sus scrofa
1.1.1.42 1.2
-
oxalosuccinate decarboxylase Sus scrofa
1.1.1.42 25 26 oxalosuccinate decarboxylase Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.41 mitochondrion
-
Cavia porcellus 5739
-
1.1.1.41 mitochondrion
-
Homo sapiens 5739
-
1.1.1.41 mitochondrion
-
Rattus norvegicus 5739
-
1.1.1.41 mitochondrion
-
Saccharomyces cerevisiae 5739
-
1.1.1.41 mitochondrion
-
Bos taurus 5739
-
1.1.1.41 mitochondrion
-
Aspergillus niger 5739
-
1.1.1.41 mitochondrion
-
Pisum sativum 5739
-
1.1.1.41 mitochondrion
-
Columba livia 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.41 Mg2+
-
Saccharomyces cerevisiae
1.1.1.41 Mg2+
-
Bos taurus
1.1.1.41 Mg2+
-
Aspergillus niger
1.1.1.41 Mg2+
-
Pisum sativum
1.1.1.41 Mn2+ requires divalent cations Saccharomyces cerevisiae
1.1.1.41 Mn2+ requires divalent cations Bos taurus
1.1.1.41 Mn2+ requires divalent cations Pisum sativum
1.1.1.42 Mg2+ absolute requirement for divalent cations Sus scrofa
1.1.1.42 Mg2+ absolute requirement for divalent cations Aspergillus niger
1.1.1.42 Mn2+ absolute requirement for divalent cations Sus scrofa
1.1.1.42 Mn2+ absolute requirement for divalent cations Aspergillus niger

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.42 61000 64000 ultracentrifugation Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.41 isocitrate + NAD+ Cavia porcellus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+ Homo sapiens
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+ Rattus norvegicus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+ Saccharomyces cerevisiae
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+ Bos taurus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+ Aspergillus niger
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+ Pisum sativum
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+ Columba livia
-
2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.42 isocitrate + NADP+ Sus scrofa
-
2-oxoglutarate + NADPH + H+ + CO2
-
r
1.1.1.42 isocitrate + NADP+ Saccharomyces cerevisiae
-
2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+ Aspergillus niger
-
2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+ Mycobacterium tuberculosis
-
2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+ Trypanosoma cruzi
-
2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+ Citrobacter freundii
-
2-oxoglutarate + NADPH + H+ + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Aspergillus niger
-
-
-
1.1.1.41 Bos taurus
-
-
-
1.1.1.41 Cavia porcellus
-
-
-
1.1.1.41 Columba livia
-
pigeon
-
1.1.1.41 Homo sapiens
-
-
-
1.1.1.41 Pisum sativum
-
pea
-
1.1.1.41 Rattus norvegicus
-
-
-
1.1.1.41 Saccharomyces cerevisiae
-
-
-
1.1.1.42 Aspergillus niger
-
-
-
1.1.1.42 Citrobacter freundii
-
-
-
1.1.1.42 Mycobacterium tuberculosis
-
-
-
1.1.1.42 Saccharomyces cerevisiae
-
-
-
1.1.1.42 Sus scrofa
-
pig
-
1.1.1.42 Trypanosoma cruzi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.41 heart
-
Cavia porcellus
-
1.1.1.41 heart
-
Homo sapiens
-
1.1.1.41 heart
-
Rattus norvegicus
-
1.1.1.41 heart
-
Bos taurus
-
1.1.1.41 muscle
-
Homo sapiens
-
1.1.1.41 muscle breast muscle Columba livia
-
1.1.1.41 placenta
-
Homo sapiens
-
1.1.1.42 heart
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 isocitrate + NAD+
-
Cavia porcellus 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+
-
Homo sapiens 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+
-
Rattus norvegicus 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+
-
Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+
-
Bos taurus 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+
-
Aspergillus niger 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+
-
Pisum sativum 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.41 isocitrate + NAD+
-
Columba livia 2-oxoglutarate + CO2 + NADH + H+
-
?
1.1.1.42 isocitrate + NADP+
-
Sus scrofa 2-oxoglutarate + NADPH + H+ + CO2
-
r
1.1.1.42 isocitrate + NADP+
-
Saccharomyces cerevisiae 2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+
-
Aspergillus niger 2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+
-
Mycobacterium tuberculosis 2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+
-
Trypanosoma cruzi 2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 isocitrate + NADP+
-
Citrobacter freundii 2-oxoglutarate + NADPH + H+ + CO2
-
?
1.1.1.42 oxalosuccinate
-
Sus scrofa 2-oxoglutarate + CO2
-
r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.42 58.3
-
isocitrate oxidative decarboxylation Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.41 6.5
-
-
Bos taurus
1.1.1.41 7.5
-
-
Saccharomyces cerevisiae
1.1.1.41 7.5
-
-
Pisum sativum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.41 6.5 8.5
-
Saccharomyces cerevisiae
1.1.1.41 6.5 8.5
-
Pisum sativum
1.1.1.42 5.6 8.5
-
Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+
-
Cavia porcellus
1.1.1.41 NAD+
-
Homo sapiens
1.1.1.41 NAD+
-
Rattus norvegicus
1.1.1.41 NAD+
-
Saccharomyces cerevisiae
1.1.1.41 NAD+
-
Bos taurus
1.1.1.41 NAD+
-
Aspergillus niger
1.1.1.41 NAD+
-
Pisum sativum
1.1.1.41 NAD+
-
Columba livia
1.1.1.42 NADP+ natural coenzyme Sus scrofa
1.1.1.42 NADP+ natural coenzyme Saccharomyces cerevisiae
1.1.1.42 NADP+ natural coenzyme Aspergillus niger
1.1.1.42 NADP+ natural coenzyme Mycobacterium tuberculosis
1.1.1.42 NADP+ natural coenzyme Trypanosoma cruzi
1.1.1.42 NADP+ natural coenzyme Citrobacter freundii
1.1.1.42 NADPH
-
Sus scrofa
1.1.1.42 NADPH
-
Saccharomyces cerevisiae
1.1.1.42 NADPH
-
Aspergillus niger
1.1.1.42 NADPH
-
Mycobacterium tuberculosis
1.1.1.42 NADPH
-
Trypanosoma cruzi
1.1.1.42 NADPH
-
Citrobacter freundii