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Literature summary extracted from

  • Drincovich, M.F.; Casati, P.; Andreo, C.S.
    NADP-malic enzyme from plants: a ubiquitous enzyme involved in different metabolic pathways (2001), FEBS Lett., 490, 1-6.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.40 malate no inhibition at pH 7.0 Egeria densa
1.1.1.40 malate no inhibition at pH 7.0 Flaveria floridana
1.1.1.40 malate inhibition at pH 7.0 Haloxylon persicum
1.1.1.40 malate no inhibition at pH 7.0 Mesembryanthemum crystallinum
1.1.1.40 malate no inhibition at pH 7.0 Triticum aestivum
1.1.1.40 malate inhibition at pH 7.0 Zea mays

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.40 0.00315
-
 NADP+
-
 Haloxylon persicum
1.1.1.40 0.0086
-
 NADP+
-
 Zea mays
1.1.1.40 0.0099
-
 NADP+
-
 Mesembryanthemum crystallinum
1.1.1.40 0.012
-
 NADP+
-
 Flaveria floridana
1.1.1.40 0.037
-
 NADP+
-
 Triticum aestivum
1.1.1.40 0.0472
-
 NADP+
-
 Egeria densa
1.1.1.40 0.08
-
 L-malate
-
 Haloxylon persicum
1.1.1.40 0.19
-
 L-malate
-
 Zea mays
1.1.1.40 0.35
-
 L-malate
-
 Mesembryanthemum crystallinum
1.1.1.40 0.46
-
 L-malate
-
 Flaveria floridana
1.1.1.40 0.96
-
 L-malate
-
 Triticum aestivum
1.1.1.40 4.5
-
 L-malate
-
 Egeria densa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.40 cytosol
-
 Solanum lycopersicum 5829
-
1.1.1.40 cytosol
-
 Mesembryanthemum crystallinum 5829
-
1.1.1.40 plastid
-
 Zea mays 9536
-
1.1.1.40 plastid
-
 Flaveria floridana 9536
-
1.1.1.40 plastid
-
 Haloxylon persicum 9536
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.40 Mg2+
-
 Solanum lycopersicum
1.1.1.40 Mg2+
-
 Mesembryanthemum crystallinum
1.1.1.40 Mg2+ Km: 0.005-0.16 mM Flaveria floridana
1.1.1.40 Mg2+ Km: 0.00146 mM Egeria densa
1.1.1.40 Mg2+ Km: 0.011-3.5 mM Haloxylon persicum
1.1.1.40 Mg2+ Km: 0.006-0.2 mM Triticum aestivum
1.1.1.40 Mg2+ Km: 0.05-0.23 mM Zea mays

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.40 62000
-
 x * 62000, SDS-PAGE Zea mays
1.1.1.40 62000
-
 x * 62000, SDS-PAGE Flaveria floridana
1.1.1.40 64000
-
 x * 64000, SDS-PAGE Mesembryanthemum crystallinum
1.1.1.40 67000
-
 x * 67000, SDS-PAGE Haloxylon persicum
1.1.1.40 72000
-
 x * 72000, SDS-PAGE Triticum aestivum
1.1.1.40 72000
-
 x * 72000, SDS-PAGE Egeria densa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.40 (S)-malate + NADP+ Zea mays enzyme plays a specialized role in bundle sheath chloroplasts, where it provides CO2 for fixation by EC 4.1.1.39 pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+ Flaveria floridana enzyme plays a specialized role in bundle sheath chloroplasts, where it provides CO2 for fixation by EC 4.1.1.39 pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+ Haloxylon persicum enzyme plays a specialized role in bundle sheath chloroplasts, where it provides CO2 for fixation by EC 4.1.1.39 pyruvate + CO2 + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.40 Aloe arborescens
-
-
-
1.1.1.40 Apium graveolens
-
-
-
1.1.1.40 Egeria densa
-
-
-
1.1.1.40 Flaveria bidentis
-
-
-
1.1.1.40 Flaveria floridana
-
-
-
1.1.1.40 Haloxylon persicum
-
-
-
1.1.1.40 Mesembryanthemum crystallinum
-
-
-
1.1.1.40 Populus sp.
-
-
-
1.1.1.40 Solanum lycopersicum
-
-
-
1.1.1.40 Triticum aestivum
-
-
-
1.1.1.40 Zea mays
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.40 bundle sheath
-
 Flaveria floridana
-
1.1.1.40 bundle sheath
-
 Haloxylon persicum
-
1.1.1.40 leaf
-
 Egeria densa
-
1.1.1.40 leaf etiolated Zea mays
-
1.1.1.40 root
-
 Zea mays
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.40 (S)-malate + NADP+
-
 Triticum aestivum pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+
-
 Zea mays pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+
-
 Mesembryanthemum crystallinum pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+
-
 Flaveria floridana pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+
-
 Haloxylon persicum pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+
-
 Egeria densa pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+ enzyme plays a specialized role in bundle sheath chloroplasts, where it provides CO2 for fixation by EC 4.1.1.39 Zea mays pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+ enzyme plays a specialized role in bundle sheath chloroplasts, where it provides CO2 for fixation by EC 4.1.1.39 Flaveria floridana pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 (S)-malate + NADP+ enzyme plays a specialized role in bundle sheath chloroplasts, where it provides CO2 for fixation by EC 4.1.1.39 Haloxylon persicum pyruvate + CO2 + NADPH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.40 ? x * 72000, SDS-PAGE Triticum aestivum
1.1.1.40 ? x * 72000, SDS-PAGE Egeria densa
1.1.1.40 ? x * 62000, SDS-PAGE Zea mays
1.1.1.40 ? x * 62000, SDS-PAGE Flaveria floridana
1.1.1.40 ? x * 67000, SDS-PAGE Haloxylon persicum
1.1.1.40 ? x * 64000, SDS-PAGE Mesembryanthemum crystallinum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.40 7.2
-
-
 Triticum aestivum
1.1.1.40 7.2
-
-
 Mesembryanthemum crystallinum
1.1.1.40 7.3
-
-
 Triticum aestivum
1.1.1.40 7.3
-
-
 Egeria densa
1.1.1.40 7.5
-
-
 Flaveria floridana
1.1.1.40 8
-
-
 Zea mays
1.1.1.40 8.2
-
-
 Haloxylon persicum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.40 NADP+ cofactor Triticum aestivum
1.1.1.40 NADP+ cofactor Zea mays
1.1.1.40 NADP+ cofactor Solanum lycopersicum
1.1.1.40 NADP+ cofactor Mesembryanthemum crystallinum
1.1.1.40 NADP+ cofactor Flaveria floridana
1.1.1.40 NADP+ cofactor Haloxylon persicum
1.1.1.40 NADP+ cofactor Egeria densa