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Literature summary extracted from

  • Iwakura, M.; Tokushige, M.; Katsuki, H.; Muramatsu, S.
    Studies on regulatory functions of malic enzymes. V. Comparative studies of malic enzymes in bacteria (1978), J. Biochem., 83, 1387-1394.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.38 aspartate 0.005 mM, 15% activation Escherichia coli W
1.1.1.38 aspartate 0.005 mM, 18% activation Citrobacter freundii
1.1.1.38 aspartate 0.005 mM, 20% activation Erwinia aroidea
1.1.1.38 aspartate 0.005 mM, 20% activation Escherichia coli K-12
1.1.1.38 aspartate 0.005 mM, 20% activation Escherichia coli B
1.1.1.38 aspartate 0.005 mM, 35% activation Proteus vulgaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.38 succinate 0.005 mM, slight inhibition Citrobacter freundii
1.1.1.38 succinate 0.005 mM, slight inhibition Escherichia coli B
1.1.1.38 succinate 0.005 mM, slight inhibition Escherichia coli K-12
1.1.1.38 succinate 0.005 mM, slight inhibition Escherichia coli W
1.1.1.38 succinate 0.005 mM, slight inhibition Klebsiella aerogenes

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.38 0.4
-
 L-malate
-
 Proteus vulgaris
1.1.1.38 0.5
-
 L-malate
-
 Erwinia aroidea
1.1.1.38 0.7
-
 L-malate
-
 Escherichia coli W
1.1.1.38 0.8
-
 L-malate
-
 Citrobacter freundii
1.1.1.38 1
-
 L-malate
-
 Escherichia coli K-12
1.1.1.38 1.2
-
 L-malate
-
 Escherichia coli B
1.1.1.38 2.2
-
 L-malate
-
 Agrobacterium tumefaciens
1.1.1.38 4.3
-
 L-malate
-
 Klebsiella aerogenes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.38 84000
-
 gel filtration Clostridium tetanomorphum
1.1.1.38 140000
-
 gel filtration Klebsiella aerogenes
1.1.1.38 180000
-
 gel filtration Proteus vulgaris
1.1.1.38 190000
-
 gel filtration Citrobacter freundii
1.1.1.38 200000
-
 gel filtration Erwinia aroidea
1.1.1.38 200000
-
 gel filtration Escherichia coli B
1.1.1.38 220000
-
-
 Escherichia coli W
1.1.1.38 220000
-
 gel filtration Escherichia coli K-12
1.1.1.38 220000
-
 gel filtration Escherichia coli B
1.1.1.38 240000
-
 gel filtration Klebsiella aerogenes
1.1.1.38 580000
-
 gel filtration Agrobacterium tumefaciens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.38 (S)-malate + NAD+ Klebsiella aerogenes
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Proteus vulgaris
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Citrobacter freundii
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Clostridium tetanomorphum
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Agrobacterium tumefaciens
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Erwinia aroidea
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Escherichia coli K-12
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Escherichia coli W
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Escherichia coli B
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+ Klebsiella aerogenes IFO 3320
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 Oxaloacetate Klebsiella aerogenes
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Proteus vulgaris
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Citrobacter freundii
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Clostridium tetanomorphum
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Agrobacterium tumefaciens
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Erwinia aroidea
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Escherichia coli K-12
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Escherichia coli W
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Escherichia coli B
-
 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate Klebsiella aerogenes IFO 3320
-
 CO2 + pyruvate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.38 Agrobacterium tumefaciens
-
-
-
1.1.1.38 Citrobacter freundii
-
-
-
1.1.1.38 Clostridium tetanomorphum
-
-
-
1.1.1.38 Erwinia aroidea
-
-
-
1.1.1.38 Escherichia coli B
-
-
-
1.1.1.38 Escherichia coli K-12
-
-
-
1.1.1.38 Escherichia coli W
-
-
-
1.1.1.38 Klebsiella aerogenes
-
-
-
1.1.1.38 Klebsiella aerogenes IFO 3320
-
-
-
1.1.1.38 Proteus vulgaris
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.38 2.3
-
-
 Escherichia coli B
1.1.1.38 5.5
-
-
 Klebsiella aerogenes
1.1.1.38 7
-
-
 Clostridium tetanomorphum
1.1.1.38 8.1
-
-
 Escherichia coli W
1.1.1.38 9
-
-
 Escherichia coli K-12
1.1.1.38 30
-
-
 Erwinia aroidea
1.1.1.38 32
-
-
 Klebsiella aerogenes
1.1.1.38 65
-
-
 Agrobacterium tumefaciens
1.1.1.38 70
-
-
 Proteus vulgaris
1.1.1.38 93
-
-
 Citrobacter freundii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.38 (S)-malate + NAD+
-
 Klebsiella aerogenes CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Klebsiella aerogenes CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Proteus vulgaris CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Proteus vulgaris CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Citrobacter freundii CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Citrobacter freundii CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Clostridium tetanomorphum CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Clostridium tetanomorphum CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Agrobacterium tumefaciens CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Agrobacterium tumefaciens CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Erwinia aroidea CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Erwinia aroidea CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Escherichia coli K-12 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Escherichia coli K-12 CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Escherichia coli W CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Escherichia coli W CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Escherichia coli B CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Escherichia coli B CO2 + pyruvate + NADH
-
 r
1.1.1.38 (S)-malate + NAD+
-
 Klebsiella aerogenes IFO 3320 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Klebsiella aerogenes IFO 3320 CO2 + pyruvate + NADH
-
 r
1.1.1.38 Oxaloacetate
-
 Klebsiella aerogenes CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Proteus vulgaris CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Citrobacter freundii CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Clostridium tetanomorphum CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Agrobacterium tumefaciens CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Erwinia aroidea CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Escherichia coli K-12 CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Escherichia coli W CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Escherichia coli B CO2 + pyruvate
-
 ir
1.1.1.38 Oxaloacetate
-
 Klebsiella aerogenes IFO 3320 CO2 + pyruvate
-
 ir

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.38 NAD+
-
 Klebsiella aerogenes
1.1.1.38 NAD+
-
 Proteus vulgaris
1.1.1.38 NAD+
-
 Citrobacter freundii
1.1.1.38 NAD+
-
 Clostridium tetanomorphum
1.1.1.38 NAD+
-
 Agrobacterium tumefaciens
1.1.1.38 NAD+
-
 Erwinia aroidea
1.1.1.38 NAD+
-
 Escherichia coli K-12
1.1.1.38 NAD+
-
 Escherichia coli W
1.1.1.38 NAD+
-
 Escherichia coli B