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Literature summary extracted from

  • Long, G.L.; Ellington, W.R.; Duda, T.F.
    Comparative enzymology and physiological role of D-lactate dehydrogenase from the foot muscle of two gastropod molluscs (1979), J. Exp. Zool., 207, 237-248.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.28 pyruvate no inhibition Cornu aspersum
1.1.1.28 pyruvate
-
 Haliotis cracherodii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.28 0.01
-
 NADH
-
 Cornu aspersum
1.1.1.28 0.02
-
 NADH
-
 Haliotis cracherodii
1.1.1.28 0.1
-
 NAD+
-
 Haliotis cracherodii
1.1.1.28 0.12
-
 NAD+
-
 Cornu aspersum
1.1.1.28 0.16
-
 pyruvate
-
 Haliotis cracherodii
1.1.1.28 0.33
-
 pyruvate
-
 Cornu aspersum
1.1.1.28 1.9
-
 (R)-lactate
-
 Haliotis cracherodii
1.1.1.28 4.4
-
 alpha-Ketobutyrate
-
 Haliotis cracherodii
1.1.1.28 4.8
-
 (R)-lactate
-
 Cornu aspersum
1.1.1.28 10
-
 alpha-Ketobutyrate
-
 Cornu aspersum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.28 (R)-lactate + NAD+ Cornu aspersum
-
 pyruvate + NADH
-
 r
1.1.1.28 (R)-lactate + NAD+ Haliotis cracherodii
-
 pyruvate + NADH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.28 Cornu aspersum
-
 land snail
-
1.1.1.28 Haliotis cracherodii
-
 black abalone
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.28
-
 Cornu aspersum
1.1.1.28
-
 Haliotis cracherodii

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.28 foot
-
 Cornu aspersum
-
1.1.1.28 foot
-
 Haliotis cracherodii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.28 (R)-lactate + NAD+
-
 Cornu aspersum pyruvate + NADH
-
 r
1.1.1.28 (R)-lactate + NAD+
-
 Haliotis cracherodii pyruvate + NADH
-
 r
1.1.1.28 alpha-ketobutyrate + NADH
-
 Cornu aspersum 2-hydroxybutyrate + NAD+
-
 ?
1.1.1.28 alpha-ketobutyrate + NADH
-
 Haliotis cracherodii 2-hydroxybutyrate + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.28 dimer 2 * 35000-40000, analytical ultracentrifugation Cornu aspersum
1.1.1.28 dimer 2 * 35000-40000, analytical ultracentrifugation Haliotis cracherodii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.28 6
-
 pyruvate reduction Cornu aspersum
1.1.1.28 6
-
 pyruvate reduction Haliotis cracherodii
1.1.1.28 8.2 9.7 (R)-lactate oxidation Cornu aspersum
1.1.1.28 8.2 9.7 (R)-lactate oxidation Haliotis cracherodii

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.28 NAD+
-
 Cornu aspersum
1.1.1.28 NAD+
-
 Haliotis cracherodii
1.1.1.28 NADH
-
 Cornu aspersum
1.1.1.28 NADH
-
 Haliotis cracherodii