EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.27 | Hg2+ | - |
Molinema dessetae | |
1.1.1.27 | iodoacetate | - |
Molinema dessetae | |
1.1.1.27 | oxalate | noncompetitive with pyruvate, competitive with lactate | Molinema dessetae | |
1.1.1.27 | oxamate | competitive with pyruvate, noncompetitive with lactate | Molinema dessetae | |
1.1.1.27 | p-chloromercuribenzoate | - |
Molinema dessetae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.27 | 0.18 | - |
NAD+ | - |
Molinema dessetae | |
1.1.1.27 | 0.25 | - |
NADH | - |
Molinema dessetae | |
1.1.1.27 | 0.34 | - |
pyruvate | - |
Molinema dessetae | |
1.1.1.27 | 2.5 | - |
(S)-lactate | - |
Molinema dessetae |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.27 | 58000 | - |
2 * 58000, isoenzyme LDH1 and LDH2, SDS-PAGE | Molinema dessetae |
1.1.1.27 | 113000 | - |
gel filtration | Molinema dessetae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.27 | Molinema dessetae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.27 | two major isoenzymes LDH1 and LDH2 | Molinema dessetae |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.27 | 80.27 | - |
- |
Molinema dessetae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.27 | (S)-lactate + NAD+ | pyruvate reduction is the favored reaction | Molinema dessetae | pyruvate + NADH + H+ | - |
r | |
1.1.1.27 | pyruvate + NADH + H+ | pyruvate reduction is the favored reaction | Molinema dessetae | (S)-lactate + NAD+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.27 | dimer | 2 * 58000, isoenzyme LDH1 and LDH2, SDS-PAGE | Molinema dessetae |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.27 | 50 | - |
15 min, 2% loss of activity | Molinema dessetae |
1.1.1.27 | 55 | - |
stable below | Molinema dessetae |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.27 | 6.8 | - |
reduction of pyruvate | Molinema dessetae |
1.1.1.27 | 8.6 | - |
oxidation of lactate | Molinema dessetae |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.27 | 6 | 8 | pH 6.0: 85% of maximal activity, pH 8.0: 45% of maximal activity, reduction of pyruvate | Molinema dessetae |
1.1.1.27 | 8 | 9.6 | pH 8.0: 60% of maximal activity, pH 9.6: 45% of maximal activity, oxidation of lactate | Molinema dessetae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.27 | NAD+ | coenzyme | Molinema dessetae | |
1.1.1.27 | NADH | coenzyme | Molinema dessetae |