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Literature summary extracted from

  • Häusler, E.; Petersen, M.; Alfermann, A.W.
    Hydroxyphenylpyruvate reductase from cell suspension cultures of Coleus blumei Benth (1991), Z. Naturforsch. C, 46, 371-376.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.237 4-hydroxyphenylpyruvate substrate inhibition Coleus scutellarioides
1.1.1.237 dihydroxyphenylpyruvate substrate inhibition Coleus scutellarioides
1.1.1.237 p-Coumaroyl-CoA 50% inhibition at 0.5 mM Coleus scutellarioides
1.1.1.237 pyruvate competitive inhibition Coleus scutellarioides
1.1.1.237 rosmarinic acid competitive inhibition Coleus scutellarioides

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.237 10
-
 4-hydroxyphenylpyruvate pH 7 Coleus scutellarioides
1.1.1.237 95
-
 NADPH pH 7 Coleus scutellarioides
1.1.1.237 130
-
 3,4-Dihydroxyphenylpyruvate pH 7 Coleus scutellarioides
1.1.1.237 190
-
 NADH pH 7 Coleus scutellarioides
1.1.1.237 250
-
 3-methoxy-4-hydroxyphenylpyruvate pH 7 Coleus scutellarioides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.237 3-(4-hydroxyphenyl)lactate + NAD+ Coleus scutellarioides
-
 4-hydroxyphenylpyruvate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.237 Coleus scutellarioides
-
-
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.237 -20°C, loss of 30% activity after 1 month Coleus scutellarioides
1.1.1.237 -20°C, loss of 85% activity after 10 weeks Coleus scutellarioides

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.237 3,4-dihydroxyphenylpyruvate + NADH + H+
-
 Coleus scutellarioides 3-(3,4-dihydroxyphenyl)lactate + NAD+
-
 r
1.1.1.237 3-(4-hydroxyphenyl)lactate + NAD+
-
 Coleus scutellarioides 4-hydroxyphenylpyruvate + NADH + H+
-
 ?
1.1.1.237 3-methoxy-4-hydroxyphenylpyruvate + NADH + H+
-
 Coleus scutellarioides 3-(3-methoxy-4-hydroxyphenyl)lactate + NAD+
-
 ?
1.1.1.237 4-hydroxyphenylpyruvate + NADH + H+
-
 Coleus scutellarioides 3-(4-hydroxyphenyl)lactate + NAD+
-
 r
1.1.1.237 beta-phenylpyruvate + NADH + H+
-
 Coleus scutellarioides 2-hydroxy-3-phenylpropanoate + NAD+
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.237 35 37
-
 Coleus scutellarioides

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.237 6.5 7
-
 Coleus scutellarioides