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Literature summary extracted from

  • Bitar, K.G.; Firca, J.R.; Loper, J.C.
    Histidinol dehydrogenase from salmonella typhimurium and escherichia coli. Purification, some characteristics and the amino acid sequence around a reactive thiol group (1977), Biochim. Biophys. Acta, 493, 429-440.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.23 N-(4-dimethylamino-3,5-dinitrophenyl)-maleimide
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O Escherichia coli reaction intermediate L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Escherichia coli
-
 L-histidine + 2 NADH + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.23 Escherichia coli
-
-
-
1.1.1.23 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.23 55°C, 40% ammonium sulfate, Sephadex G-50, DEAE-cellulose, crystallization Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.23 55°C, 40% ammonium sulfate, Sephadex G-50, DEAE-cellulose, crystallization Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.23 12.5
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.23 12.71
-
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Escherichia coli L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Escherichia coli L-histidine + NADH + H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 2 H+
-
 ?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
 Escherichia coli L-histidine + 2 NADH + 2 H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.23 NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.23 NAD+
-
 Escherichia coli