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Literature summary extracted from

  • Reen, R.K.; Jamwal, D.S.; Taneja, S.C.; Koul, J.L.; Dubey, R.K.; Wiebel, F.J.; Singh, J.
    Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine (1993), Biochem. Pharmacol., 46, 229-238.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.22 piperine stronger inhibition with intestinal cell enzyme than with rat liver enzyme Cavia porcellus
1.1.1.22 piperine non-competitive, reversible, non-pH-dependent, 90% inhibition at concentration 0.05 mM and 10% inhibition at concentration 0.01 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.22 0.015
-
 UDPglucose pH 9.4 Rattus norvegicus
1.1.1.22 0.035
-
 UDPglucose pH 8.6 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.22 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.22 UDPglucose + NAD+ + H2O Cavia porcellus
-
 UDPglucuronate + NADH
-
 ?
1.1.1.22 UDPglucose + NAD+ + H2O Rattus norvegicus
-
 UDPglucuronate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.22 Cavia porcellus
-
-
-
1.1.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.22 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.22 liver
-
 Cavia porcellus
-
1.1.1.22 liver
-
 Rattus norvegicus
-
1.1.1.22 small intestine
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.22 3-OH-benzopyrene + NAD+
-
 Rattus norvegicus ?
-
 ?
1.1.1.22 UDP-glucose + 2 NAD+ + H2O
-
 Cavia porcellus UDP-glucuronate + 2 NADH + 2 H+
-
 ?
1.1.1.22 UDP-glucose + 2 NAD+ + H2O
-
 Rattus norvegicus UDP-glucuronate + 2 NADH + 2 H+
-
 ?
1.1.1.22 UDPglucose + NAD+ + H2O
-
 Cavia porcellus UDPglucuronate + NADH
-
 ?
1.1.1.22 UDPglucose + NAD+ + H2O
-
 Rattus norvegicus UDPglucuronate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.22 8.6
-
 two pH optima, pH 8.6 and pH 9.4 Rattus norvegicus
1.1.1.22 9.4
-
 two pH optima, pH 8.6 and pH 9.4 Rattus norvegicus