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Literature summary extracted from

  • Barski, O.A.; Gabbay, K.H.; Bohren, K.M.
    The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity (1996), Biochemistry, 35, 14276-14280.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.2
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 3,3'-tetramethylenglutaric acid
-
 Homo sapiens
1.1.1.2 AL1576
-
 Homo sapiens
1.1.1.2 Alrestatin
-
 Homo sapiens
1.1.1.2 FK366
-
 Homo sapiens
1.1.1.2 ponalrestat
-
 Homo sapiens
1.1.1.2 sorbinil
-
 Homo sapiens
1.1.1.2 Tolrestat
-
 Homo sapiens
1.1.1.2 zopolrestat
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.038
-
 p-Carboxybenzaldehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 0.11
-
 p-Carboxybenzaldehyde aldehyde reductase, mutant R308A Homo sapiens
1.1.1.2 0.16
-
 p-nitrobenzaldehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 0.17
-
 Succinic semialdehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 0.2
-
 Succinic semialdehyde aldehyde reductase, mutant R308A Homo sapiens
1.1.1.2 0.25
-
 p-nitrobenzaldehyde aldehyde reductase, mutant R308A Homo sapiens
1.1.1.2 0.38
-
 p-nitrobenzaldehyde mutant R311A Homo sapiens
1.1.1.2 1.7
-
 DL-glyceraldehyde wild-type aldehyde reductase Homo sapiens
1.1.1.2 1.7
-
 DL-glyceraldehyde wild type enzyme, at pH 7.0 and 25°C Homo sapiens
1.1.1.2 2.2
-
 DL-glyceraldehyde aldehyde reductase, mutant R311A Homo sapiens
1.1.1.2 2.2
-
 DL-glyceraldehyde mutant enzyme R311A, at pH 7.0 and 25°C Homo sapiens
1.1.1.2 2.3
-
 DL-glyceraldehyde aldehyde reductase, mutant R308A Homo sapiens
1.1.1.2 2.3
-
 DL-glyceraldehyde mutant enzyme R308A, at pH 7.0 and 25°C Homo sapiens
1.1.1.2 4
-
 p-Carboxybenzaldehyde aldehyde reductase, mutant R311A Homo sapiens
1.1.1.2 4.2
-
 D-glucuronate wild-type aldehyde reductase Homo sapiens
1.1.1.2 7.5
-
 D-glucuronate aldehyde reductase, mutant R308A Homo sapiens
1.1.1.2 14.1
-
 Succinic semialdehyde aldehyde reductase, mutant R311A Homo sapiens
1.1.1.2 364
-
 D-glucuronate aldehyde reductase, mutant R311A Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 35000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Homo sapiens
-
 4-hydroxybutyrate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Homo sapiens P14550 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.2 DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Homo sapiens p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Homo sapiens p-nitrobenzylalcohol + NADP+
-
 ?
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Homo sapiens 4-hydroxybutyrate + NADP+
-
 r