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Literature summary extracted from

  • Kawasaki, N.; Tanimoto, T.; Tanaka, A.
    Characterization of aldose reductase and aldehyde reductase from rat testis (1989), Biochim. Biophys. Acta, 996, 30-36.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 Alconil
-
 Rattus norvegicus
1.1.1.2 E79175
-
 Rattus norvegicus
1.1.1.2 epalrestat
-
 Rattus norvegicus
1.1.1.2 NaCl
-
 Rattus norvegicus
1.1.1.2 NH4Cl
-
 Rattus norvegicus
1.1.1.2 sorbinil
-
 Rattus norvegicus
1.1.1.2 Statil
-
 Rattus norvegicus
1.1.1.2 Tolrestat
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.006
-
 NADPH
-
 Rattus norvegicus
1.1.1.2 6.42
-
 D-glucuronate
-
 Rattus norvegicus
1.1.1.2 8.35
-
 DL-glyceraldehyde
-
 Rattus norvegicus
1.1.1.2 2080
-
 D-xylose
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 41000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Rattus norvegicus
-
 glycerol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 testis
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 6.84
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 D-xylose + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.1.1.2 glycerol + NADP+
-
 Rattus norvegicus DL-glyceraldehyde + NADPH + H+
-
 ?
1.1.1.2 L-glyceraldehyde + NADPH
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 additional information enzyme is virtually inactive for aldo-sugars Rattus norvegicus ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.2 NADPH aldehyde reductase II utilizes only NADPH as cofactor Rattus norvegicus