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Literature summary extracted from

  • Das, B.; Srivastava, S.K.
    Purification and properties of aldehyde reductases from human placenta (1985), Biochim. Biophys. Acta, 840, 324-333.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 Li2SO4 both aldehyde reductase I and II are susceptible to inhibition Homo sapiens
1.1.1.2 NaCl aldehyde reductase I and II Homo sapiens
1.1.1.2 sorbinil
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.02
-
 3-Pyridinecarboxaldehyde AR I Homo sapiens
1.1.1.2 0.02
-
 NADPH AR II Homo sapiens
1.1.1.2 0.05
-
 NADPH AR I Homo sapiens
1.1.1.2 0.07
-
 glyceraldehyde AR I Homo sapiens
1.1.1.2 0.07
-
 glyceraldehyde aldehyde reductase I, at pH 7.3 and 37°C Homo sapiens
1.1.1.2 0.21
-
 propionaldehyde AR I Homo sapiens
1.1.1.2 2.53
-
 glucuronate AR II Homo sapiens
1.1.1.2 2.63
-
 propionaldehyde AR II Homo sapiens
1.1.1.2 6.67
-
 glyceraldehyde AR II Homo sapiens
1.1.1.2 6.67
-
 glyceraldehyde aldehyde reductase II, at pH 7.0 and 37°C Homo sapiens
1.1.1.2 8.61
-
 3-Pyridinecarboxaldehyde AR II Homo sapiens
1.1.1.2 215
-
 D-glucose AR I Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 32500
-
 1 * 32500, SDS-PAGE Homo sapiens
1.1.1.2 32500
-
 1 * 32500 + 1 * 39000 Homo sapiens
1.1.1.2 32700
-
 aldehyde reductase II, gel filtration Homo sapiens
1.1.1.2 39000
-
 1 * 32500 + 1 * 39000 Homo sapiens
1.1.1.2 74000
-
 aldehyde reductase I, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Cavia porcellus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Cavia porcellus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Cavia porcellus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Homo sapiens
-
 glycerol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Cavia porcellus
-
 guinea pig
-
1.1.1.2 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2 aldehyde reductase I and II Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 placenta
-
 Cavia porcellus
-
1.1.1.2 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Cavia porcellus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Homo sapiens 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 D-glucose + NADPH placenta aldehyde reductase I Homo sapiens ? + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH aldehyde reductase II Homo sapiens L-gulonate + NADP+
-
 ?
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Cavia porcellus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Cavia porcellus glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 propionaldehyde + NADPH
-
 Homo sapiens propanol + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 dimer 1 * 32500 + 1 * 39000 Homo sapiens
1.1.1.2 monomer 1 * 32500, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 aldo-keto reductase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 6
-
 aldehyde reductaseI Homo sapiens
1.1.1.2 7
-
 aldehyde reductase II Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.2 NADH aldehyde reductase I Homo sapiens
1.1.1.2 NADPH aldehyde reductase II utilizes only NADPH as cofactor Homo sapiens