EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.2 | SO42- | - |
Gallus sp. |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.2 | 3,3'-tetramethylenglutaric acid | AR1 and AR3 | Gallus sp. | |
1.1.1.2 | 3,3'-tetramethylenglutaric acid | - |
Homo sapiens | |
1.1.1.2 | 3,3'-tetramethylenglutaric acid | - |
Rattus norvegicus | |
1.1.1.2 | chlorpromazine | - |
Bos taurus | |
1.1.1.2 | chlorpromazine | isozyme AR3 | Gallus sp. | |
1.1.1.2 | chlorpromazine | - |
Rattus norvegicus | |
1.1.1.2 | indomethacin | - |
Gallus sp. | |
1.1.1.2 | p-chloromercuribenzoate | - |
Gallus sp. | |
1.1.1.2 | Phenobarbital | - |
Bos taurus | |
1.1.1.2 | Phenobarbital | - |
Gallus sp. | |
1.1.1.2 | Phenobarbital | - |
Homo sapiens | |
1.1.1.2 | Phenobarbital | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.2 | 0.002 | - |
NADPH | AR2 | Gallus sp. | |
1.1.1.2 | 0.003 | - |
NADPH | AR1 | Gallus sp. | |
1.1.1.2 | 0.003 | - |
NADPH | AR3 | Gallus sp. | |
1.1.1.2 | 0.052 | - |
NADH | AR2 | Gallus sp. | |
1.1.1.2 | 0.052 | - |
NADH | aldehyde reductase 2, at pH 6.0 and 25°C | Gallus sp. | |
1.1.1.2 | 0.056 | - |
p-Carboxybenzaldehyde | AR1 | Gallus sp. | |
1.1.1.2 | 0.099 | - |
androstane-3,17-dione | AR2 | Gallus sp. | |
1.1.1.2 | 0.11 | - |
5alpha-dihydrotestosterone | AR2 | Gallus sp. | |
1.1.1.2 | 0.43 | - |
D-glyceraldehyde | AR2 | Gallus sp. | |
1.1.1.2 | 0.46 | - |
1,2-Cyclohexanedione | AR3 | Gallus sp. | |
1.1.1.2 | 0.8 | - |
1,2-Cyclohexanedione | AR2 | Gallus sp. | |
1.1.1.2 | 1.1 | - |
D-galacturonate | AR1 | Gallus sp. | |
1.1.1.2 | 1.2 | - |
p-nitrobenzaldehyde | AR1 | Gallus sp. | |
1.1.1.2 | 1.6 | - |
Phenylglyoxal | AR1 | Gallus sp. | |
1.1.1.2 | 2.7 | - |
ethylacetoacetate | AR2 | Gallus sp. | |
1.1.1.2 | 2.8 | - |
methylglyoxal | AR1 | Gallus sp. | |
1.1.1.2 | 3 | - |
pyridine 3-aldehyde | AR1 | Gallus sp. | |
1.1.1.2 | 3.7 | - |
Indole-3-acetaldehyde | AR1 | Gallus sp. | |
1.1.1.2 | 3.9 | - |
m-nitrobenzaldehyde | AR1 | Gallus sp. | |
1.1.1.2 | 4 | - |
pyridine 4-aldehyde | AR1 | Gallus sp. | |
1.1.1.2 | 4 | - |
5alpha-dihydrotestosterone | AR3 | Gallus sp. | |
1.1.1.2 | 4.5 | - |
D-glucuronate | AR1 | Gallus sp. | |
1.1.1.2 | 4.6 | - |
o-nitrobenzaldehyde | AR1 | Gallus sp. | |
1.1.1.2 | 4.9 | - |
L-glyceraldehyde | AR2 | Gallus sp. | |
1.1.1.2 | 8.2 | - |
D-glyceraldehyde | AR3 | Gallus sp. | |
1.1.1.2 | 10.8 | - |
diacetyl | AR1, AR3 | Gallus sp. | |
1.1.1.2 | 11.1 | - |
L-glyceraldehyde | AR3 | Gallus sp. | |
1.1.1.2 | 13 | - |
androstane-3,17-dione | AR3 | Gallus sp. | |
1.1.1.2 | 19.6 | - |
D-glucuronolactone | AR2 | Gallus sp. | |
1.1.1.2 | 26 | - |
ethylacetoacetate | AR3 | Gallus sp. | |
1.1.1.2 | 67 | - |
D-glucuronolactone | AR1 | Gallus sp. | |
1.1.1.2 | 111 | - |
ribose | AR2 | Gallus sp. | |
1.1.1.2 | 160 | - |
xylose | AR2 | Gallus sp. | |
1.1.1.2 | 270 | - |
D-xylose | AR1 | Gallus sp. |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.2 | cytosol | - |
Homo sapiens | 5829 | - |
1.1.1.2 | cytosol | - |
Rattus norvegicus | 5829 | - |
1.1.1.2 | cytosol | - |
Bos taurus | 5829 | - |
1.1.1.2 | cytosol | - |
Gallus sp. | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.2 | Na2SO4 | 400 mM, AR2, relative activity 150% | Gallus sp. |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.2 | 30000 | - |
- |
Homo sapiens |
1.1.1.2 | 30000 | - |
- |
Bos taurus |
1.1.1.2 | 30000 | - |
Ar1 and AR3, gel filtration | Gallus sp. |
1.1.1.2 | 32000 | - |
- |
Homo sapiens |
1.1.1.2 | 32000 | - |
- |
Rattus norvegicus |
1.1.1.2 | 32000 | - |
- |
Bos taurus |
1.1.1.2 | 32000 | - |
AR2, gel filtration | Gallus sp. |
1.1.1.2 | 39000 | - |
AR1and AR3, SDS-PAGE | Gallus sp. |
1.1.1.2 | 39500 | - |
AR2, SDS-PAGE | Gallus sp. |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.2 | ethylacetoacetate + NADPH | Rattus norvegicus | - |
ethyl L-(+)-3-hydroxybutyrate + NADP+ | - |
? | |
1.1.1.2 | ethylacetoacetate + NADPH | Gallus sp. | - |
ethyl L-(+)-3-hydroxybutyrate + NADP+ | - |
? | |
1.1.1.2 | lauryl aldehyde + NADPH | Gallus sp. | isozyme AR3 | lauryl alcohol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.2 | Bos taurus | - |
ox | - |
1.1.1.2 | Gallus sp. | - |
chicken | - |
1.1.1.2 | Homo sapiens | - |
human | - |
1.1.1.2 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.2 | - |
Gallus sp. |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.2 | brain | - |
Homo sapiens | - |
1.1.1.2 | brain | - |
Rattus norvegicus | - |
1.1.1.2 | brain | - |
Bos taurus | - |
1.1.1.2 | brain | - |
Gallus sp. | - |
1.1.1.2 | heart | - |
Homo sapiens | - |
1.1.1.2 | heart | - |
Rattus norvegicus | - |
1.1.1.2 | heart | - |
Bos taurus | - |
1.1.1.2 | heart | - |
Gallus sp. | - |
1.1.1.2 | kidney | - |
Homo sapiens | - |
1.1.1.2 | kidney | - |
Rattus norvegicus | - |
1.1.1.2 | kidney | - |
Bos taurus | - |
1.1.1.2 | liver | - |
Homo sapiens | - |
1.1.1.2 | liver | - |
Rattus norvegicus | - |
1.1.1.2 | liver | - |
Bos taurus | - |
1.1.1.2 | muscle | - |
Homo sapiens | - |
1.1.1.2 | muscle | leg muscle | Gallus sp. | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.2 | 5.86 | - |
AR2 | Gallus sp. |
1.1.1.2 | 19.7 | - |
AR1 | Gallus sp. |
1.1.1.2 | 19.9 | - |
AR3 | Gallus sp. |
1.1.1.2 | 20 | - |
- |
Rattus norvegicus |
1.1.1.2 | 20 | - |
AR1 and AR3 | Gallus sp. |
EC Number | Storage Stability | Organism |
---|---|---|
1.1.1.2 | -20°C can be stored in 20% glycerol/10 mM phosphate buffer, pH 8, 0.5 mg/ml without any loss of activity for 1 month | Gallus sp. |
1.1.1.2 | 4°C purified enzymes are stable for at least 2 days, then gradually loses activity during storage | Gallus sp. |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.2 | 1,2-cyclohexanedione + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | 3-pyridinecarboxaldehyde + NADPH | - |
Homo sapiens | 3-pyridinemethanol + NADP+ | - |
r | |
1.1.1.2 | 3-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 3-pyridinemethanol + NADP+ | - |
r | |
1.1.1.2 | 3-pyridinecarboxaldehyde + NADPH | - |
Bos taurus | 3-pyridinemethanol + NADP+ | - |
? | |
1.1.1.2 | 3-pyridinecarboxaldehyde + NADPH | - |
Gallus sp. | 3-pyridinemethanol + NADP+ | - |
? | |
1.1.1.2 | 4-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 4-pyridinemethanol + NADP+ | - |
r | |
1.1.1.2 | 4-pyridinecarboxaldehyde + NADPH | - |
Gallus sp. | 4-pyridinemethanol + NADP+ | - |
r | |
1.1.1.2 | 5alpha-dihydrotestosterone + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | acetoin + NADPH + H+ | isozyme AR3 | Gallus sp. | butan-2,3-diol + NADP+ | - |
? | |
1.1.1.2 | androstane-3,17-dione + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | D-galacturonate + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
? | |
1.1.1.2 | D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
? | |
1.1.1.2 | D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
? | |
1.1.1.2 | D-glucuronate + NADPH | - |
Gallus sp. | L-gulonate + NADP+ | - |
? | |
1.1.1.2 | D-glucuronolactone + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
1.1.1.2 | D-glucuronolactone + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
1.1.1.2 | D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
1.1.1.2 | D-glyceraldehyde + NADPH + H+ | - |
Gallus sp. | glycerol + NADP+ | - |
r | |
1.1.1.2 | D-ribose + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | D-xylose + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
1.1.1.2 | D-xylose + NADPH | - |
Bos taurus | ? + NADP+ | - |
? | |
1.1.1.2 | D-xylose + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | diacetyl + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | ethylacetoacetate + NADPH | - |
Rattus norvegicus | ethyl L-(+)-3-hydroxybutyrate + NADP+ | - |
? | |
1.1.1.2 | ethylacetoacetate + NADPH | - |
Gallus sp. | ethyl L-(+)-3-hydroxybutyrate + NADP+ | - |
? | |
1.1.1.2 | glycolaldehyde + NADPH | - |
Gallus sp. | ethane-1,2-diol + NADP+ | - |
r | |
1.1.1.2 | indol-3-ylacetaldehyde + NADPH | - |
Gallus sp. | indol-3-ethanol + NADP+ | - |
r | |
1.1.1.2 | L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
1.1.1.2 | L-glyceraldehyde + NADPH | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
1.1.1.2 | L-glyceraldehyde + NADPH | - |
Gallus sp. | glycerol + NADP+ | - |
r | |
1.1.1.2 | L-xylose + NADPH | - |
Gallus sp. | ? + NADP+ | - |
? | |
1.1.1.2 | lauryl aldehyde + NADPH | isozyme AR3 | Gallus sp. | lauryl alcohol + NADP+ | - |
? | |
1.1.1.2 | m-nitrobenzaldehyde + NADPH | - |
Homo sapiens | m-nitrobenzylalcohol + NADP+ | - |
r | |
1.1.1.2 | m-nitrobenzaldehyde + NADPH | - |
Gallus sp. | m-nitrobenzylalcohol + NADP+ | - |
r | |
1.1.1.2 | methylglyoxal + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
1.1.1.2 | methylglyoxal + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
r | |
1.1.1.2 | methylglyoxal + NADPH | - |
Gallus sp. | ? + NADP+ | - |
r | |
1.1.1.2 | n-butyraldehyde + NADPH | - |
Homo sapiens | n-butanol + NADP+ | - |
r | |
1.1.1.2 | n-butyraldehyde + NADPH | - |
Gallus sp. | n-butanol + NADP+ | - |
r | |
1.1.1.2 | o-nitrobenzaldehyde + NADPH | - |
Gallus sp. | o-nitrobenzylalcohol + NADP+ | - |
r | |
1.1.1.2 | p-carboxybenzaldehyde + NADPH | - |
Homo sapiens | p-carboxybenzyl alcohol + NADP+ | - |
r | |
1.1.1.2 | p-carboxybenzaldehyde + NADPH | - |
Rattus norvegicus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
1.1.1.2 | p-carboxybenzaldehyde + NADPH | - |
Bos taurus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
1.1.1.2 | p-carboxybenzaldehyde + NADPH | - |
Gallus sp. | p-carboxybenzyl alcohol + NADP+ | - |
r | |
1.1.1.2 | p-nitrobenzaldehyde + NADPH | - |
Homo sapiens | p-nitrobenzylalcohol + NADP+ | - |
r | |
1.1.1.2 | p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
1.1.1.2 | p-nitrobenzaldehyde + NADPH | - |
Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
1.1.1.2 | p-nitrobenzaldehyde + NADPH | - |
Gallus sp. | p-nitrobenzylalcohol + NADP+ | - |
r | |
1.1.1.2 | phenylglyoxal + NADPH | - |
Gallus sp. | ? + NADP+ | - |
r | |
1.1.1.2 | pyridine 4-aldehyde + NADH + H+ | - |
Gallus sp. | 4-pyridinemethanol + NAD+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.2 | monomer | - |
Homo sapiens |
1.1.1.2 | monomer | - |
Rattus norvegicus |
1.1.1.2 | monomer | - |
Bos taurus |
1.1.1.2 | monomer | 1 * 39500, AR1, SDS-PAGE | Gallus sp. |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.2 | 50 | - |
- |
Homo sapiens |
1.1.1.2 | 50 | - |
AR1 and AR3 loses about 30% activity after 10 min, Ar2 loses more than 60% | Gallus sp. |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.2 | 6 | 6.5 | AR1 and AR3 | Gallus sp. |
1.1.1.2 | 6 | - |
- |
Homo sapiens |
1.1.1.2 | 6 | - |
- |
Rattus norvegicus |
1.1.1.2 | 6 | - |
AR2, sharp acidic pH | Gallus sp. |