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Literature summary extracted from

  • Daly, A.K.; Mantle, T.J.
    Purification and characterization of the multiple forms of aldehyde reductase in ox kidney (1982), Biochem. J., 205, 373-380.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 benzodiazepine
-
 Bos taurus
1.1.1.2 Sodium barbitone
-
 Bos taurus
1.1.1.2 Sodium barbitone
-
 Sus scrofa
1.1.1.2 sodium valproate
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.002
-
 NADPH AR1 Bos taurus
1.1.1.2 0.003
-
 NADPH G2 Bos taurus
1.1.1.2 0.007
-
 NADPH AR4 Bos taurus
1.1.1.2 0.008
-
 NADPH AR3 Bos taurus
1.1.1.2 0.008
-
 3-Pyridinecarboxaldehyde AR3 Bos taurus
1.1.1.2 0.0084
-
 p-nitrobenzaldehyde AR3 Bos taurus
1.1.1.2 0.009
-
 menadione AR4 Bos taurus
1.1.1.2 0.018
-
 p-Carboxybenzaldehyde AR1 Bos taurus
1.1.1.2 0.028
-
 Succinic semialdehyde AR4 Bos taurus
1.1.1.2 0.029
-
 Succinic semialdehyde AR1 Bos taurus
1.1.1.2 0.03
-
 menadione G2 Bos taurus
1.1.1.2 0.036
-
 Succinic semialdehyde G2 Bos taurus
1.1.1.2 0.064
-
 Succinic semialdehyde AR3 Bos taurus
1.1.1.2 0.071
-
 p-nitrobenzaldehyde AR1 Bos taurus
1.1.1.2 0.129
-
 p-nitrobenzaldehyde G2 Bos taurus
1.1.1.2 0.258
-
 p-Carboxybenzaldehyde AR3 Bos taurus
1.1.1.2 0.262
-
 p-nitrobenzaldehyde AR4 Bos taurus
1.1.1.2 0.751
-
 3-Pyridinecarboxaldehyde G2 Bos taurus
1.1.1.2 0.934
-
 3-Pyridinecarboxaldehyde AR1 Bos taurus
1.1.1.2 1.18
-
 cyclohexanone G2 Bos taurus
1.1.1.2 1.29
-
 D-glucuronic acid AR1 Bos taurus
1.1.1.2 2.48
-
 D-glucuronic acid G2 Bos taurus
1.1.1.2 2.99
-
 D-glucuronic acid AR3 Bos taurus
1.1.1.2 5
-
 3-Pyridinecarboxaldehyde AR4 Bos taurus
1.1.1.2 36.77
-
 cyclohexanone AR4 Bos taurus
1.1.1.2 41
-
 xylose AR3 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 25500
-
 G2, gel filtration Bos taurus
1.1.1.2 26300
-
 gel filtration Bos taurus
1.1.1.2 30000
-
-
 Sus scrofa
1.1.1.2 30000
-
 AR1, gel filtration Bos taurus
1.1.1.2 31000
-
 AR3, gel filtration Bos taurus
1.1.1.2 33500
-
 1 * 33500, AR1, SDS-PAGE Bos taurus
1.1.1.2 34700
-
 1 * 34700, AR3, SDS-PAGE Bos taurus
1.1.1.2 56000
-
 AR4, gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Cavia porcellus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Sus scrofa
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Bos taurus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Cavia porcellus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Cavia porcellus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADP+ Sus scrofa
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+ Bos taurus
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Sus scrofa
-
 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Bos taurus
-
 4-hydroxybutyrate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
 ox
-
1.1.1.2 Cavia porcellus
-
 guinea pig
-
1.1.1.2 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Sus scrofa
1.1.1.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Cavia porcellus
-
1.1.1.2 brain
-
 Sus scrofa
-
1.1.1.2 brain
-
 Bos taurus
-
1.1.1.2 kidney
-
 Cavia porcellus
-
1.1.1.2 kidney
-
 Sus scrofa
-
1.1.1.2 kidney
-
 Bos taurus
-
1.1.1.2 liver
-
 Cavia porcellus
-
1.1.1.2 liver
-
 Sus scrofa
-
1.1.1.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 0.55
-
 AR3 Bos taurus
1.1.1.2 8.94
-
 AR1 Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.1.1.2 -20°C AR1 stable for at least 6 months Bos taurus
1.1.1.2 -20°C AR3 loses most of its activity Bos taurus
1.1.1.2 4°C AR1 loses all activity after storage for 1 month Bos taurus
1.1.1.2 4°C AR3 stable for at least 1 month in presence of NaN3 Bos taurus
1.1.1.2 4°C in 0.01% NaN3 stable for at least 1 month, the gel-filtered enzyme is stable for approximately 2 weeks Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Cavia porcellus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Sus scrofa 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH AR3 Bos taurus 3-pyridinemethanol + NADP+
-
 ?
1.1.1.2 cyclohexanol + NADP+
-
 Bos taurus cyclohexanone + NADPH + H+
-
 r
1.1.1.2 cyclohexanone + NADPH
-
 Sus scrofa cyclohexanol + NADP+
-
 ?
1.1.1.2 cyclohexanone + NADPH G2 Bos taurus cyclohexanol + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Bos taurus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH AR1 Bos taurus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Cavia porcellus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 D-xylose + NADPH
-
 Sus scrofa ? + NADP+
-
 ?
1.1.1.2 D-xylose + NADPH AR3 Bos taurus ? + NADP+
-
 ?
1.1.1.2 L-glyceraldehyde + NADPH
-
 Cavia porcellus glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Sus scrofa D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Bos taurus D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Sus scrofa D-glucuronic acid + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Bos taurus D-glucuronic acid + NADP+
-
 r
1.1.1.2 menadione + NADPH G2 Bos taurus ? + NADP+
-
 ?
1.1.1.2 additional information
-
 Sus scrofa ?
-
 ?
1.1.1.2 additional information AR1 is not active with neutral sugars or with ketones, AR3 is capable of reducing neutral sugars, G2 is active with ketones, AR4 is inactive with 15-oxoprostaglandin B1 Bos taurus ?
-
 ?
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Sus scrofa p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH AR1 Bos taurus p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Sus scrofa p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH AR1 Bos taurus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 propane-1,2-diol + NADP+
-
 Sus scrofa lactaldehyde + NADPH
-
 r
1.1.1.2 propane-1,2-diol + NADP+
-
 Bos taurus lactaldehyde + NADPH
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Sus scrofa 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Bos taurus 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ AR1 Bos taurus 4-hydroxybutyrate + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 monomer
-
 Sus scrofa
1.1.1.2 monomer 1 * 33500, AR1, SDS-PAGE Bos taurus
1.1.1.2 monomer 1 * 34700, AR3, SDS-PAGE Bos taurus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 aldehyde/ketone reductase
-
 Cavia porcellus
1.1.1.2 hexogenate dehydrogenase
-
 Bos taurus