Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Turner, A.J.; Hryszko, J.
    Isolation and characterization of rat liver aldehyde reductase (1980), Biochim. Biophys. Acta, 613, 256-265.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.2 adenosine
-
 Rattus norvegicus
1.1.1.2 Trifluperazine
-
 Rattus norvegicus

Application

EC Number Application Comment Organism
1.1.1.2 medicine
-
 Sus scrofa
1.1.1.2 medicine ability of aldehyde reductase from liver to reduce certain cancer chemotherapeutic antibiotics suggested a role for this enzyme in drug metabolism Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 2',5'-ADP
-
 Rattus norvegicus
1.1.1.2 2,4-dimethylglutaric acid
-
 Rattus norvegicus
1.1.1.2 3,3'-tetramethylenglutaric acid
-
 Rattus norvegicus
1.1.1.2 3,3-dimethylglutaric acid
-
 Rattus norvegicus
1.1.1.2 Alrestatin AY22,284A Rattus norvegicus
1.1.1.2 Blue dextran
-
 Rattus norvegicus
1.1.1.2 Cibacron blue F3GA
-
 Rattus norvegicus
1.1.1.2 morin
-
 Rattus norvegicus
1.1.1.2 Phenobarbital
-
 Rattus norvegicus
1.1.1.2 Phenobarbital
-
 Sus scrofa
1.1.1.2 Procion Reed HE3B
-
 Rattus norvegicus
1.1.1.2 quercetin
-
 Rattus norvegicus
1.1.1.2 quercetin
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.031
-
 p-Carboxybenzaldehyde
-
 Rattus norvegicus
1.1.1.2 0.059
-
 p-hydroxyphenylglycolaldehyde
-
 Rattus norvegicus
1.1.1.2 0.23
-
 p-nitrobenzaldehyde
-
 Rattus norvegicus
1.1.1.2 0.26
-
 pyridine 3-aldehyde
-
 Rattus norvegicus
1.1.1.2 0.91
-
 p-hydroxyphenylacetaldehyde
-
 Rattus norvegicus
1.1.1.2 1.3
-
 DL-glyceraldehyde
-
 Rattus norvegicus
1.1.1.2 2.2
-
 D-glucuronate
-
 Rattus norvegicus
1.1.1.2 4.5
-
 benzaldehyde
-
 Rattus norvegicus
1.1.1.2 29
-
 Chloral hydrate
-
 Rattus norvegicus
1.1.1.2 670
-
 D-xylose
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Sus scrofa
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Rattus norvegicus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADP+ Rattus norvegicus
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+ Sus scrofa
-
 D-glucuronic acid + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Rattus norvegicus
-
 rat
-
1.1.1.2 Rattus norvegicus
-
 Wistar albino
-
1.1.1.2 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Sus scrofa
-
1.1.1.2 kidney
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Sus scrofa
-
1.1.1.2 liver
-
 Rattus norvegicus
-
1.1.1.2 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Rattus norvegicus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Sus scrofa 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Rattus norvegicus benzyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Sus scrofa benzyl alcohol + NADP+
-
 r
1.1.1.2 chloral hydrate + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 D-xylose + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.1.1.2 D-xylose + NADPH
-
 Sus scrofa ? + NADP+
-
 ?
1.1.1.2 glycerol + NADP+
-
 Rattus norvegicus DL-glyceraldehyde + NADPH + H+
-
 ?
1.1.1.2 L-glyceraldehyde + NADPH
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Rattus norvegicus D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Sus scrofa D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Rattus norvegicus D-glucuronic acid + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Sus scrofa D-glucuronic acid + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Rattus norvegicus p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Sus scrofa p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylacetaldehyde + NADPH + H+
-
 Rattus norvegicus p-hydroxyphenylethanol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylacetaldehyde + NADPH + H+
-
 Sus scrofa p-hydroxyphenylethanol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylglycolaldehyde + NADPH
-
 Rattus norvegicus 4-hydroxyphenylethylalcohol + NADP+
-
 r
1.1.1.2 p-hydroxyphenylglycolaldehyde + NADPH
-
 Sus scrofa 4-hydroxyphenylethylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Sus scrofa p-nitrobenzylalcohol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 daunorubicin reductase
-
 Rattus norvegicus
1.1.1.2 daunorubicin reductase
-
 Sus scrofa
1.1.1.2 hexogenate dehydrogenase
-
 Rattus norvegicus
1.1.1.2 mevaldate reductase
-
 Rattus norvegicus