Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Croteau, R.; Hooper, C.L.; Felton, M.
    Biosynthesis of monoterpenes. Partial purification and characterization of a bicyclic monoterpenol dehydrogenase from sage (Salvia officinalis) (1978), Arch. Biochem. Biophys., 188, 182-193.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.198 (+)-Camphor 27% inhibition at 0.5 mM Salvia officinalis
1.1.1.198 (-)-Thujol competitive inhibition of (+)-borneol oxidation Salvia officinalis
1.1.1.198 8-hydroxyquinoline 57% inhibition at 1 mM Salvia officinalis
1.1.1.198 Borate inhibition of borneol oxidation Salvia officinalis
1.1.1.198 Cu2+ 85% inhibition at 2 mM Salvia officinalis
1.1.1.198 ethylenediaminetetraacetate slight inhibition at 1 mM Salvia officinalis
1.1.1.198 Hg2+ nearly complete inhibition at 2 mM Salvia officinalis
1.1.1.198 iodoacetamide 41% inhibition at 1 mM Salvia officinalis
1.1.1.198 N-ethylmaleimide 53% inhibition at 1 mM Salvia officinalis
1.1.1.198 NaCN slight inhibition at 1 mM Salvia officinalis
1.1.1.198 NADH 46% inhibition at 1 mM Salvia officinalis
1.1.1.198 NaN3 slight inhibition at 1 mM Salvia officinalis
1.1.1.198 o-phenanthroline slight inhibition at 1 mM Salvia officinalis
1.1.1.198 p-hydroxymercuribenzoate 50% inhibition at 0.05 mM Salvia officinalis
1.1.1.198 Pb2+ 26% inhibition at 2 mM Salvia officinalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.198 0.03
-
(+)-borneol
-
Salvia officinalis
1.1.1.198 0.041
-
(-)-Thujol
-
Salvia officinalis
1.1.1.198 0.07
-
NAD+
-
Salvia officinalis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.198 91000
-
gel filtration Salvia officinalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.198 (+)-borneol + NAD+ Salvia officinalis B-site stereospecific, partially reversible (+)-camphor + NADH
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.198 Salvia officinalis
-
sage
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.198 near homogeneity, chromatography techniques, affinity chromatography Salvia officinalis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.198 leaf
-
Salvia officinalis
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.198 0°C, 0.1 M sodium phosphate, pH 8.0, 15% glycerol, 20 mM 2-mercaptoethanol, 3 days, 25% loss of activity Salvia officinalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.198 (+)-borneol + NAD+ B-site stereospecific, partially reversible Salvia officinalis (+)-camphor + NADH
-
r
1.1.1.198 (+)-dihydrocarveol + NAD+ poor substrate Salvia officinalis (-)-dihydrocarvone + NADH
-
?
1.1.1.198 (+)-endo-fenchol + NAD+ 26% of the activity compared to (+)-borneol Salvia officinalis 1,3,3-trimethyl-bicyclo[2.2.1]heptan-2-one + NADH
-
?
1.1.1.198 (+)-isoborneol + NAD+ nearly the same activity compared to (+)-borneol Salvia officinalis (+)-isocamphor + NADH
-
?
1.1.1.198 (-)-borneol + NAD+ 36% of the activity compared to (+)-borneol Salvia officinalis (-)-camphor + NADH + H+
-
?
1.1.1.198 (-)-endo-fenchol + NAD+ poor substrate Salvia officinalis 1,3,3-trimethyl-bicyclo[2.2.1]heptan-2-one + NADH
-
?
1.1.1.198 (-)-isoborneol + NAD+ 30% of the activity compared to (+)-borneol Salvia officinalis (-)-isocamphor + NADH
-
?
1.1.1.198 (-)-neothujol + NAD+ 65% of the activity compared to (+)-borneol Salvia officinalis (-)-neothujone + NADH
-
?
1.1.1.198 (-)-thujol + NAD+ 2fold higher activity than for (+)-borneol Salvia officinalis (-)-thujone + NADH
-
?
1.1.1.198 (1R)-menthol + NAD+ poor substrate Salvia officinalis (1R)-trans-p-menthan-3-one + NADH
-
?
1.1.1.198 geraniol + NAD+ poor substrate Salvia officinalis geranial + NADH + H+
-
?
1.1.1.198 nerol + NAD+ poor substrate Salvia officinalis neryl aldehyde + NADH
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.198 8
-
-
Salvia officinalis

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.198 8
-
most stable around Salvia officinalis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.198 NAD+
-
Salvia officinalis
1.1.1.198 NADP+ 25% as efficient as NAD+ Salvia officinalis