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Literature summary extracted from

  • Sato, S.; Kador, P.F.
    Human kidney aldose and aldehyde reductases (1993), J. Diabetes Complicat., 7, 179-187.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.19 Al 1576
-
 Canis lupus familiaris
1.1.1.19 Al 1576
-
 Homo sapiens
1.1.1.19 Al 1576
-
 Rattus norvegicus
1.1.1.19 ponalrestat
-
 Canis lupus familiaris
1.1.1.19 ponalrestat
-
 Homo sapiens
1.1.1.19 ponalrestat
-
 Rattus norvegicus
1.1.1.19 Tolrestat
-
 Canis lupus familiaris
1.1.1.19 Tolrestat
-
 Homo sapiens
1.1.1.19 Tolrestat
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.19 1.6
-
 D-glucuronate
-
 Canis lupus familiaris
1.1.1.19 2.1
-
 L-gulonate
-
 Canis lupus familiaris
1.1.1.19 3.1
-
 D-glucuronate
-
 Homo sapiens
1.1.1.19 4.8
-
 L-gulonate
-
 Homo sapiens
1.1.1.19 6.2
-
 D-glucuronate
-
 Rattus norvegicus
1.1.1.19 7.6
-
 L-gulonate
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.19 36000
-
 gel filtration Homo sapiens
1.1.1.19 39000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.19 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH Rattus norvegicus
-
 L-gulonate + NADP+
-
 r
1.1.1.19 L-gulonate + NADP+ Homo sapiens
-
 D-glucuronate + NADPH
-
 r
1.1.1.19 L-gulonate + NADP+ Rattus norvegicus
-
 D-glucuronate + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.19 Canis lupus familiaris
-
-
-
1.1.1.19 Homo sapiens
-
-
-
1.1.1.19 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.19
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.19 kidney
-
 Canis lupus familiaris
-
1.1.1.19 kidney cortex Homo sapiens
-
1.1.1.19 kidney cortex Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.19 1.339
-
 highly purified enzyme, substrate NADPH Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.19 D-aldose + NADPH
-
 Rattus norvegicus L-alditol + NADP+
-
 r
1.1.1.19 D-aldose + NADPH i.e. D-xylose, D-glucose, D-galactose are reduced with 100fold less active than D-glucuronate Homo sapiens L-alditol + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH + H+
-
 Canis lupus familiaris L-gulonate + NADP+
-
 r
1.1.1.19 L-gulonate + NADP+
-
 Homo sapiens D-glucuronate + NADPH
-
 r
1.1.1.19 L-gulonate + NADP+
-
 Rattus norvegicus D-glucuronate + NADPH
-
 r
1.1.1.19 L-gulonate + NADP+
-
 Canis lupus familiaris D-glucuronate + NADPH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.19 monomer 1 * 39000, SDS-PAGE Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.19 NADP+
-
 Homo sapiens
1.1.1.19 NADP+
-
 Rattus norvegicus
1.1.1.19 NADP+
-
 Canis lupus familiaris
1.1.1.19 NADPH
-
 Homo sapiens
1.1.1.19 NADPH
-
 Rattus norvegicus
1.1.1.19 NADPH
-
 Canis lupus familiaris