Any feedback?
Literature summary extracted from
- Identity of dimeric dihydrodiol dehydrogenase as NADP+-dependent D-xylose dehydrogenase in pig liver (2001), Chem. Biol. Interact., 130-132, 775-784.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.179 | KCl | increase in activity about 2fold | Sus scrofa |  |
| 1.1.1.179 | MgCl2 | increase in activity about 4fold | Sus scrofa | |
| 1.1.1.179 | additional information | - |
Macaca fuscata | |
| 1.1.1.179 | additional information | higher salt concentration elevates the activity | Sus scrofa |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.1.1.179 | H79Q | large increase in Km for coenzyme and substrates | Macaca fuscata |
| 1.1.1.179 | Y180F | - |
Macaca fuscata |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.179 | high salt concentration | recombinant H79Q mutant | Macaca fuscata | |
| 1.3.1.20 | 4-hydroxyacetophenone | - |
Canis sp. | |
| 1.3.1.20 | 4-hydroxyacetophenone | - |
Macaca fuscata | |
| 1.3.1.20 | 4-hydroxyacetophenone | inhibits dihydrodiol and D-xylose dehydrogenase activity | Sus scrofa | |
| 1.3.1.20 | isoascorbic acid | - |
Canis sp. | |
| 1.3.1.20 | isoascorbic acid | - |
Macaca fuscata | |
| 1.3.1.20 | isoascorbic acid | inhibits dihydrodiol and D-xylose dehydrogenase activity | Sus scrofa | |
| 1.3.1.20 | KCl | increase in Km-value for D-xylose and NADP+ | Sus scrofa | |
| 1.3.1.20 | MgCl2 | - |
Macaca fuscata | |
| 1.3.1.20 | MgCl2 | increase in Km-value for D-xylose and NADP+ | Sus scrofa | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.179 | 0.0011 | - |
NADP+ | + 20 mM MgCl2 | Sus scrofa | |
| 1.1.1.179 | 1.3 | - |
D-xylose | 25 mM Tris + 20 mM MgCl2 | Sus scrofa | |
| 1.1.1.179 | 6.4 | - |
D-xylose | - |
Macaca fuscata | |
| 1.1.1.179 | 6.5 | - |
D-xylose | - |
Sus scrofa | |
| 1.3.1.20 | additional information | - |
additional information | Km for diverse sugars | Sus scrofa | |
| 1.3.1.20 | additional information | - |
additional information | Km for diverse sugars | Oryctolagus cuniculus | |
| 1.3.1.20 | additional information | - |
additional information | Km for diverse sugars | Macaca fuscata | |
| 1.3.1.20 | additional information | - |
additional information | Km for diverse sugars | Canis sp. | |
| 1.3.1.20 | 0.8 | - |
D-xylose | - |
Sus scrofa | |
| 1.3.1.20 | 1.6 | - |
D-xylose | - |
Canis sp. | |
| 1.3.1.20 | 4.4 | - |
D-xylose | - |
Oryctolagus cuniculus | |
| 1.3.1.20 | 4.4 | - |
D-xylose | - |
Macaca fuscata | |
| 1.3.1.20 | 6.4 | - |
D-xylose | - |
Macaca fuscata | |
| 1.3.1.20 | 6.5 | - |
D-xylose | liver D-xylose dehydrogenase | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.179 | D-xylose + NADP+ | Homo sapiens | - |
D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | Sus scrofa | - |
D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | Oryctolagus cuniculus | - |
D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | Canis lupus familiaris | - |
D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | Macaca fuscata | - |
D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.179 | Canis lupus familiaris | - |
- |
- |
| 1.1.1.179 | Homo sapiens | - |
- |
- |
| 1.1.1.179 | Macaca fuscata | - |
- |
- |
| 1.1.1.179 | Oryctolagus cuniculus | - |
- |
- |
| 1.1.1.179 | Sus scrofa | - |
- |
- |
| 1.3.1.20 | Canis sp. | - |
dog | - |
| 1.3.1.20 | Homo sapiens | - |
- |
- |
| 1.3.1.20 | Macaca fuscata | - |
japanese monkey | - |
| 1.3.1.20 | Oryctolagus cuniculus | - |
rabbit | - |
| 1.3.1.20 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.179 | - |
Sus scrofa |
| 1.1.1.179 | - |
Oryctolagus cuniculus |
| 1.1.1.179 | - |
Canis lupus familiaris |
| 1.1.1.179 | - |
Macaca fuscata |
| 1.3.1.20 | - |
Macaca fuscata |
| 1.3.1.20 | - |
Canis sp. |
| 1.3.1.20 | co-purification of dihydrodiol and D-xylose dehydrogenase activities indicating that EC 1.1.1.179 and EC 1.3.1.20 are the same enzyme | Sus scrofa |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.1.1.179 | D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH + H+ | ordered bi-bi mechanism | Sus scrofa | |
| 1.3.1.20 | trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ | D-xylose dehydrogenase EC 1.1.1.179 and dihydrodiol dehydrogenase EC 1.3.1.20 both follow an ordered bi-bi mechanism and are thus considered the same enzyme | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.179 | intestine | exclusively | Homo sapiens | - |
| 1.1.1.179 | kidney | exclusively | Macaca fuscata | - |
| 1.1.1.179 | lens | - |
Sus scrofa | - |
| 1.1.1.179 | lens | - |
Oryctolagus cuniculus | - |
| 1.1.1.179 | lens | - |
Canis lupus familiaris | - |
| 1.1.1.179 | liver | - |
Sus scrofa | - |
| 1.1.1.179 | liver | - |
Canis lupus familiaris | - |
| 1.1.1.179 | additional information | enzyme activity is found in almost all tissues | Sus scrofa | - |
| 1.3.1.20 | intestine | - |
Homo sapiens | - |
| 1.3.1.20 | intestine | - |
Canis sp. | - |
| 1.3.1.20 | kidney | - |
Macaca fuscata | - |
| 1.3.1.20 | kidney | - |
Canis sp. | - |
| 1.3.1.20 | lens | - |
Sus scrofa | - |
| 1.3.1.20 | lens | - |
Oryctolagus cuniculus | - |
| 1.3.1.20 | lens | - |
Canis sp. | - |
| 1.3.1.20 | liver | - |
Homo sapiens | - |
| 1.3.1.20 | liver | - |
Sus scrofa | - |
| 1.3.1.20 | liver | - |
Macaca fuscata | - |
| 1.3.1.20 | liver | - |
Canis sp. | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.179 | 7.6 | - |
- |
Sus scrofa |
| 1.1.1.179 | 9 | - |
- |
Macaca fuscata |
| 1.3.1.20 | additional information | - |
substrate specificities for diverse sugars | Sus scrofa |
| 1.3.1.20 | additional information | - |
substrate specificities for diverse sugars | Oryctolagus cuniculus |
| 1.3.1.20 | additional information | - |
substrate specificities for diverse sugars | Macaca fuscata |
| 1.3.1.20 | additional information | - |
substrate specificities for diverse sugars | Canis sp. |
| 1.3.1.20 | 0.011 | - |
extract, substrate naphthalene dihydrodiol | Sus scrofa |
| 1.3.1.20 | 0.024 | - |
extract, substrate naphthalene dihydrodiol | Macaca fuscata |
| 1.3.1.20 | 0.038 | - |
extract, substrate naphthalene dihydrodiol | Canis sp. |
| 1.3.1.20 | 7.3 | - |
co-purified enzyme, D-xylose dehydrogenase activity | Sus scrofa |
| 1.3.1.20 | 8 | - |
co-purified enzyme, dihydrodiol dehydrogenase activity | Sus scrofa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.179 | D-xylose + NADP+ | - |
Homo sapiens | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | - |
Sus scrofa | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | - |
Oryctolagus cuniculus | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | - |
Canis lupus familiaris | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | D-xylose + NADP+ | - |
Macaca fuscata | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.1.1.179 | additional information | - |
Sus scrofa | ? | - |
? | |
| 1.1.1.179 | additional information | catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 | Homo sapiens | ? | - |
? | |
| 1.1.1.179 | additional information | catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 | Oryctolagus cuniculus | ? | - |
? | |
| 1.1.1.179 | additional information | catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 | Canis lupus familiaris | ? | - |
? | |
| 1.1.1.179 | additional information | catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 | Macaca fuscata | ? | - |
? | |
| 1.1.1.179 | trans-benzene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Sus scrofa | ? | - |
? | |
| 1.1.1.179 | trans-benzene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Oryctolagus cuniculus | ? | - |
? | |
| 1.1.1.179 | trans-benzene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Canis lupus familiaris | ? | - |
? | |
| 1.1.1.179 | trans-benzene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Macaca fuscata | ? | - |
? | |
| 1.1.1.179 | trans-naphthalene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Sus scrofa | ? | - |
? | |
| 1.1.1.179 | trans-naphthalene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Oryctolagus cuniculus | ? | - |
? | |
| 1.1.1.179 | trans-naphthalene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Canis lupus familiaris | ? | - |
? | |
| 1.1.1.179 | trans-naphthalene dihydrodiol + NADP+ | dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 | Macaca fuscata | ? | - |
? | |
| 1.3.1.20 | 2-deoxy-D-glucose + NADP+ | low activity | Sus scrofa | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | 2-deoxy-D-glucose + NADP+ | low activity | Oryctolagus cuniculus | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | 2-deoxy-D-glucose + NADP+ | low activity | Macaca fuscata | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | 2-deoxy-D-glucose + NADP+ | low activity | Canis sp. | 2-deoxy-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-arabinose + NADP+ | low activity | Sus scrofa | D-arabinono-1,4-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-arabinose + NADP+ | low activity | Oryctolagus cuniculus | D-arabinono-1,4-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-arabinose + NADP+ | low activity | Macaca fuscata | D-arabinono-1,4-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-arabinose + NADP+ | low activity | Canis sp. | D-arabinono-1,4-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-galactose + NADP+ | low activity | Sus scrofa | D-galactono-1,5-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-galactose + NADP+ | low activity | Oryctolagus cuniculus | D-galactono-1,5-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-galactose + NADP+ | low activity | Macaca fuscata | D-galactono-1,5-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-galactose + NADP+ | low activity | Canis sp. | D-galactono-1,5-lactone + NADPH | - |
? | |
| 1.3.1.20 | D-glucose + NADP+ | low activity | Sus scrofa | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-glucose + NADP+ | low activity | Oryctolagus cuniculus | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-glucose + NADP+ | low activity | Macaca fuscata | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-glucose + NADP+ | low activity | Canis sp. | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-ribose + NADP+ | - |
Sus scrofa | ? | - |
? | |
| 1.3.1.20 | D-ribose + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.3.1.20 | D-ribose + NADP+ | - |
Macaca fuscata | ? | - |
? | |
| 1.3.1.20 | D-ribose + NADP+ | - |
Canis sp. | ? | - |
? | |
| 1.3.1.20 | D-xylose + NADP+ | also low activity with L-xylose | Sus scrofa | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-xylose + NADP+ | also low activity with L-xylose | Oryctolagus cuniculus | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-xylose + NADP+ | also low activity with L-xylose | Macaca fuscata | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | D-xylose + NADP+ | also low activity with L-xylose | Canis sp. | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
| 1.3.1.20 | trans-naphthalene dihydrodiol + NAD(P)+ | - |
Homo sapiens | ? | - |
? | |
| 1.3.1.20 | trans-naphthalene dihydrodiol + NAD(P)+ | - |
Sus scrofa | ? | - |
? | |
| 1.3.1.20 | trans-naphthalene dihydrodiol + NAD(P)+ | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1.3.1.20 | trans-naphthalene dihydrodiol + NAD(P)+ | - |
Macaca fuscata | ? | - |
? | |
| 1.3.1.20 | trans-naphthalene dihydrodiol + NAD(P)+ | - |
Canis sp. | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.20 | DD | - |
Homo sapiens |
| 1.3.1.20 | DD | - |
Sus scrofa |
| 1.3.1.20 | DD | - |
Oryctolagus cuniculus |
| 1.3.1.20 | DD | - |
Macaca fuscata |
| 1.3.1.20 | DD | - |
Canis sp. |
| 1.3.1.20 | dihydrodiol dehydrogenase | - |
Homo sapiens |
| 1.3.1.20 | dihydrodiol dehydrogenase | - |
Sus scrofa |
| 1.3.1.20 | dihydrodiol dehydrogenase | - |
Oryctolagus cuniculus |
| 1.3.1.20 | dihydrodiol dehydrogenase | - |
Macaca fuscata |
| 1.3.1.20 | dihydrodiol dehydrogenase | - |
Canis sp. |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.20 | 25 | - |
- |
Homo sapiens |
| 1.3.1.20 | 25 | - |
assay at, substrates naphthalene dihydrodiol and NADP+ | Sus scrofa |
| 1.3.1.20 | 25 | - |
assay at, substrates naphthalene dihydrodiol and NADP+ | Macaca fuscata |
| 1.3.1.20 | 25 | - |
assay at, substrates naphthalene dihydrodiol and NADP+ | Canis sp. |
| 1.3.1.20 | 30 | - |
assay at, substrate D-xylose, pH 10.0 | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.179 | 7.5 | - |
assay at | Sus scrofa |
| 1.1.1.179 | 7.5 | - |
assay at | Oryctolagus cuniculus |
| 1.1.1.179 | 7.5 | - |
assay at | Canis lupus familiaris |
| 1.1.1.179 | 7.5 | - |
assay at | Macaca fuscata |
| 1.1.1.179 | 10 | - |
dihydrodiol dehydrogenase activity assay at | Sus scrofa |
| 1.1.1.179 | 10 | - |
dihydrodiol dehydrogenase activity assay at | Oryctolagus cuniculus |
| 1.1.1.179 | 10 | - |
dihydrodiol dehydrogenase activity assay at | Canis lupus familiaris |
| 1.1.1.179 | 10 | - |
dihydrodiol dehydrogenase activity assay at | Macaca fuscata |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.179 | additional information | - |
Sus scrofa | |
| 1.1.1.179 | additional information | Tyr71, His79, Lys97 involved in coenzyme binding | Macaca fuscata | |
| 1.1.1.179 | NADP+ | - |
Homo sapiens | |
| 1.1.1.179 | NADP+ | - |
Sus scrofa | |
| 1.1.1.179 | NADP+ | - |
Oryctolagus cuniculus | |
| 1.1.1.179 | NADP+ | - |
Canis lupus familiaris | |
| 1.1.1.179 | NADP+ | Tyr71, His79, Lys97 involved in coenzyme binding | Macaca fuscata | |
| 1.3.1.20 | NADP+ | - |
Homo sapiens | |
| 1.3.1.20 | NADP+ | - |
Sus scrofa | |
| 1.3.1.20 | NADP+ | - |
Oryctolagus cuniculus | |
| 1.3.1.20 | NADP+ | - |
Macaca fuscata | |
| 1.3.1.20 | NADP+ | - |
Canis sp. | |
| 1.3.1.20 | NADPH | - |
Homo sapiens | |
| 1.3.1.20 | NADPH | - |
Sus scrofa | |
| 1.3.1.20 | NADPH | - |
Oryctolagus cuniculus | |
| 1.3.1.20 | NADPH | - |
Macaca fuscata | |
| 1.3.1.20 | NADPH | - |
Canis sp. | |
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