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Literature summary extracted from
- Characterization of sepiapterin reductase activity from Drosophila melanogaster (1996), Comp. Biochem. Physiol. B, 113, 131-136.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.153 | N-acetyldopamine | noncompetitive | Drosophila melanogaster |  |
| 1.1.1.153 | N-acetylserotonin | noncompetitive | Drosophila melanogaster | |
| 1.1.1.153 | N-methoxyacetylserotonin | noncompetitive | Drosophila melanogaster | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.153 | 0.153 | - |
sepiapterin | estimated | Drosophila melanogaster | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.153 | 6-(S)-lactoyl-7,8-dihydropterin + NADPH | Drosophila melanogaster | - |
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ | - |
? | |
| 1.1.1.153 | 6-(S)-lactoyl-7,8-dihydropterin + NADPH | Drosophila melanogaster Oregon R | - |
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.153 | Drosophila melanogaster | - |
- |
- |
| 1.1.1.153 | Drosophila melanogaster Oregon R | - |
- |
- |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.153 | 0.022 | - |
measured in female flies, value lower in males | Drosophila melanogaster |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.153 | 6-(S)-lactoyl-7,8-dihydropterin + NADPH | - |
Drosophila melanogaster | 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ | - |
? | |
| 1.1.1.153 | 6-(S)-lactoyl-7,8-dihydropterin + NADPH | - |
Drosophila melanogaster Oregon R | 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ | - |
? | |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.153 | 40 | 46 | - |
Drosophila melanogaster |
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