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Literature summary extracted from

  • Iijima, Y.; Ueno, T.; Sasagawa, K.; Yamazaki, M.
    Inhibition of 15-hydroxyprostaglandin dehydrogenase by papaverine (1978), Biochem. Biophys. Res. Commun., 80, 484-489.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.141 additional information no activation by cAMP Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 additional information no inhibition by Ca2+ Canis lupus familiaris
1.1.1.141 papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Canis lupus familiaris
1.1.1.141 papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Cavia porcellus
1.1.1.141 papaverine
-
 Gallus gallus
1.1.1.141 papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Rattus norvegicus
1.1.1.141 papaverine the inhibition is noncompetitive with prostaglandin E2, uncompetitive with NAD+, and reversible Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.01
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate pH 7.4, 37°C Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.141 soluble
-
 Cavia porcellus
-
-
1.1.1.141 soluble
-
 Sus scrofa
-
-
1.1.1.141 soluble
-
 Canis lupus familiaris
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Cavia porcellus first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Rattus norvegicus first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Sus scrofa first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Canis lupus familiaris first step in prostaglandin catabolism (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Canis lupus familiaris
-
-
-
1.1.1.141 Cavia porcellus
-
-
-
1.1.1.141 Gallus gallus
-
-
-
1.1.1.141 Rattus norvegicus
-
-
-
1.1.1.141 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.141 native enzyme partially from heart Cavia porcellus
1.1.1.141 native enzyme partially from kidney Rattus norvegicus
1.1.1.141 native soluble enzyme partially from heart ventricular tissue by ultracentrifugation, ammonium sulfate fractionation, gel filtration, and anion exchange chromatography Canis lupus familiaris
1.1.1.141 native soluble enzyme partially from lung Sus scrofa
1.1.1.141 native soluble enzyme partially from lung by ultracentrifugation, ammonium sulfate fractionation and anion exchange chromatography Cavia porcellus
1.1.1.141 partial Gallus gallus
1.1.1.141 partial Cavia porcellus
1.1.1.141 partial Rattus norvegicus
1.1.1.141 partial Sus scrofa
1.1.1.141 partial Canis lupus familiaris

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 heart
-
 Gallus gallus
-
1.1.1.141 heart
-
 Cavia porcellus
-
1.1.1.141 heart
-
 Rattus norvegicus
-
1.1.1.141 heart
-
 Sus scrofa
-
1.1.1.141 heart
-
 Canis lupus familiaris
-
1.1.1.141 kidney
-
 Gallus gallus
-
1.1.1.141 kidney
-
 Cavia porcellus
-
1.1.1.141 kidney
-
 Rattus norvegicus
-
1.1.1.141 kidney
-
 Sus scrofa
-
1.1.1.141 kidney
-
 Canis lupus familiaris
-
1.1.1.141 lung
-
 Cavia porcellus
-
1.1.1.141 lung
-
 Rattus norvegicus
-
1.1.1.141 lung
-
 Sus scrofa
-
1.1.1.141 lung
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Cavia porcellus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Rattus norvegicus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ first step in prostaglandin catabolism Canis lupus familiaris (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Cavia porcellus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Rattus norvegicus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Canis lupus familiaris (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-hydroxyprostaglandin dehydrogenase
-
 Cavia porcellus
1.1.1.141 15-hydroxyprostaglandin dehydrogenase
-
 Rattus norvegicus
1.1.1.141 15-hydroxyprostaglandin dehydrogenase
-
 Sus scrofa
1.1.1.141 15-hydroxyprostaglandin dehydrogenase
-
 Canis lupus familiaris
1.1.1.141 15-OH-PGDH
-
 Cavia porcellus
1.1.1.141 15-OH-PGDH
-
 Rattus norvegicus
1.1.1.141 15-OH-PGDH
-
 Sus scrofa
1.1.1.141 15-OH-PGDH
-
 Canis lupus familiaris
1.1.1.141 NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
 Cavia porcellus
1.1.1.141 NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
 Rattus norvegicus
1.1.1.141 NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
 Sus scrofa
1.1.1.141 NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
 Canis lupus familiaris

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.141 37
-
 assay at Cavia porcellus
1.1.1.141 37
-
 assay at Rattus norvegicus
1.1.1.141 37
-
 assay at Sus scrofa
1.1.1.141 37
-
 assay at Canis lupus familiaris

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.141 7.4
-
 assay at Cavia porcellus
1.1.1.141 7.4
-
 assay at Rattus norvegicus
1.1.1.141 7.4
-
 assay at Sus scrofa
1.1.1.141 8.7
-
 assay at Canis lupus familiaris

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Cavia porcellus
1.1.1.141 NAD+
-
 Rattus norvegicus
1.1.1.141 NAD+
-
 Sus scrofa
1.1.1.141 NAD+
-
 Canis lupus familiaris

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.141 0.026
-
 papaverine
-
 Cavia porcellus
1.1.1.141 0.026
-
 papaverine pH 7.4, 37°C Cavia porcellus
1.1.1.141 0.068
-
 papaverine enzyme from kidney Canis lupus familiaris
1.1.1.141 0.068
-
 papaverine kidney enzyme, pH 7.4, 37°C Canis lupus familiaris
1.1.1.141 0.07
-
 papaverine enzyme from heart Canis lupus familiaris
1.1.1.141 0.07
-
 papaverine heart enzyme, pH 7.4, 37°C Canis lupus familiaris
1.1.1.141 0.098
-
 papaverine
-
 Gallus gallus
1.1.1.141 0.098
-
 papaverine pH 7.4, 37°C Cavia porcellus
1.1.1.141 0.12
-
 papaverine
-
 Sus scrofa
1.1.1.141 0.12
-
 papaverine pH 7.4, 37°C Sus scrofa
1.1.1.141 0.4
-
 papaverine
-
 Rattus norvegicus
1.1.1.141 0.4
-
 papaverine kidney enzyme, pH 7.4, 37°C Rattus norvegicus